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dc.contributor.authorDhakal, Binod
dc.contributor.authorPatel, Sagar
dc.contributor.authorGirnius, Saulius
dc.contributor.authorBachegowda, Lohith
dc.contributor.authorFraser, Raphael
dc.contributor.authorDavila, Omar
dc.contributor.authorKanate, Abraham S
dc.contributor.authorAssal, Amer
dc.contributor.authorHanbali, Amr
dc.contributor.authorBashey, Asad
dc.contributor.authorPawarode, Attaphol
dc.contributor.authorFreytes, César O
dc.contributor.authorLee, Cindy
dc.contributor.authorVesole, David
dc.contributor.authorCornell, Robert Frank
dc.contributor.authorHildebrandt, Gerhard C
dc.contributor.authorMurthy, Hemant S
dc.contributor.authorLazarus, Hillard M
dc.contributor.authorCerny, Jan
dc.contributor.authorYared, Jean A
dc.contributor.authorSchriber, Jeffrey
dc.contributor.authorBerdeja, Jesus
dc.contributor.authorStockerl-Goldstein, Keith
dc.contributor.authorMeehan, Kenneth
dc.contributor.authorHolmberg, Leona
dc.contributor.authorSolh, Melhem
dc.contributor.authorDiaz, Miguel Angel
dc.contributor.authorKharfan-Dabaja, Mohamed A
dc.contributor.authorFarhadfar, Nosha
dc.contributor.authorBashir, Qaiser
dc.contributor.authorMunker, Reinhold
dc.contributor.authorOlsson, Richard F
dc.contributor.authorGale, Robert P
dc.contributor.authorBayer, Ruthlee-Lu
dc.contributor.authorSeo, Sachiko
dc.contributor.authorChhabra, Saurabh
dc.contributor.authorHashmi, Shahrukh
dc.contributor.authorBadawy, Sherif M
dc.contributor.authorNishihori, Taiga
dc.contributor.authorGonsalves, Wilson
dc.contributor.authorNieto, Yago
dc.contributor.authorEfebera, Yvonne
dc.contributor.authorKumar, Shaji
dc.contributor.authorShah, Nina
dc.contributor.authorQazilbash, Muzaffar
dc.contributor.authorHari, Parameswaran
dc.contributor.authorD'Souza, Anita
dc.date.accessioned2021-06-21T14:17:39Z
dc.date.available2021-06-21T14:17:39Z
dc.date.issued2020-04-20
dc.identifier.urihttp://hdl.handle.net/10713/16053
dc.descriptionCorrection at 10.1038/s41375-021-01304-3: Acknowledgments needs reference to grant numbers U24CA233032 and OT3HL147741 removed.en_US
dc.description.abstractThe outcomes of patients with primary plasma cell leukemia (pPCL) after undergoing hematopoietic cell transplantation (HCT) in the novel agent era are unknown. We report outcomes of 348 patients with pPCL receiving autologous (auto-) HCT (n = 277) and allogeneic (allo-) HCT (n = 71) between 2008 and 2015. Median age was 60 years and 56 years for auto- and allo-HCT respectively. For auto-HCT, the 4-year outcomes were: non-relapse mortality (NRM) 7% (4-11%), relapse (REL) 76% (69-82%), progression-free survival (PFS) 17% (13-23%), and overall survival (OS) 28% (22-35%). Karnofsky performance status (KPS) > 90 and ≥very good partial response (VGPR) predicted superior OS in multi-variate analysis for auto-HCT. For allo-HCT, the 4-year outcomes were: NRM 12% (5-21%), REL 69% (56-81%), PFS 19% (10-31%), and OS 31% (19-44%). Compared with prior CIBMTR pPCL patients (1995-2006), inferior survival was noted in the current cohort (3-year OS, 39% vs. 38% in allo-HCT, and 62% vs. 35% in auto-HCT) respectively. However, we noted an increased HCT utilization, from 12% (7-21%) in 1995 to 46% (34-64%) in 2009 using SEER data (available till 2009). Despite modern induction translating to higher proportion receiving HCT, the outcomes remain poor in pPCL patients, mainly derived by high relapse rates post-HCT.en_US
dc.description.urihttps://doi.org/10.1038/s41375-020-0830-0en_US
dc.description.urihttps://doi.org/10.1038/s41375-021-01304-3en_US
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc7572530/en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofLeukemiaen_US
dc.subject.meshHematopoietic Stem Cell Transplantationen_US
dc.subject.meshLeukemia, Plasma Cellen_US
dc.titleHematopoietic cell transplantation utilization and outcomes for primary plasma cell leukemia in the current eraen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41375-020-0830-0
dc.identifier.pmid32313109
dc.source.volume34
dc.source.issue12
dc.source.beginpage3338
dc.source.endpage3347
dc.source.countryUnited States
dc.source.countryEngland


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