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dc.contributor.authorSo, Jennifer Y
dc.contributor.authorO'Hara, Nathan N
dc.contributor.authorKenaa, Blaine
dc.contributor.authorWilliams, John G
dc.contributor.authordeBorja, Christopher L
dc.contributor.authorSlejko, Julia F
dc.contributor.authorZafari, Zafar
dc.contributor.authorSokolow, Michael
dc.contributor.authorZimand, Paul
dc.contributor.authorDeming, Meagan
dc.contributor.authorMarx, Jason
dc.contributor.authorPollak, Andrew N
dc.contributor.authorReed, Robert M
dc.date.accessioned2021-06-17T19:00:22Z
dc.date.available2021-06-17T19:00:22Z
dc.date.issued2021-06-12
dc.identifier.urihttp://hdl.handle.net/10713/16043
dc.description.abstractBackground: The COVID-19 pandemic has led to widespread implementation of public health measures, such as stay-at-home orders, social distancing, and masking mandates. In addition to decreasing spread of SARS-CoV2, these measures also impact the transmission of seasonal viral pathogens, which are common triggers of COPD exacerbations. Whether reduced viral prevalence mediates reduction in COPD exacerbation rates is unknown. Methods: We performed retrospective analysis of data from a large, multicenter healthcare system to assess admission trends associated with community viral prevalence and with initiation of COVID-19 pandemic control measures. We applied difference-in-differences (DiD) analysis to compare season-matched weekly frequency of hospital admissions for COPD before and after implementation of public health measures for COVID-19. Community viral prevalence was estimated using regional Center for Disease Control and Prevention test positivity data and correlated to COPD admissions. Results: Data involving 4,422 COPD admissions demonstrated a season-matched 53% decline in COPD admissions during COVID-19 pandemic, which correlated to community viral burden (r=0.73; 95% CI: 0.67 to 0.78) and represented a 36% greater decline over admission frequencies observed in other medical conditions less affected by respiratory viral infections (IRR, 0.64; 95% CI, 0.57 to 0.71, p<0.001). The post-COVID-19 decline in COPD admissions was most pronounced in patients with fewer comorbidities and without recurrent admissions. Conclusion: The implementation of public health measures during the COVID-19 pandemic was associated with decreased COPD admissions. These changes are plausibly explained by reduced prevalence of seasonal respiratory viruses.en_US
dc.description.urihttps://doi.org/10.1016/j.amjmed.2021.05.008en_US
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc8196237/en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofAmerican Journal of Medicineen_US
dc.rightsCopyright © 2021 Elsevier Ltd. All rights reserved.en_US
dc.subjectCOPDen_US
dc.subjectCOVIDen_US
dc.subjectcommunity viral infectionsen_US
dc.subjectexacerbationsen_US
dc.titleDecline in COPD Admissions During the COVID-19 Pandemic Associated with Lower Burden of Community Respiratory Viral Infectionsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.amjmed.2021.05.008
dc.identifier.pmid34126098
dc.source.countryUnited States


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