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dc.contributor.authorDePalma, Ralph G
dc.contributor.authorHayes, Virginia W
dc.contributor.authorO'Leary, Timothy J
dc.date.accessioned2021-06-17T13:33:04Z
dc.date.available2021-06-17T13:33:04Z
dc.date.issued2021-05-28en_US
dc.identifier.urihttp://hdl.handle.net/10713/16041
dc.description.abstractThis report provides perspectives concerning dual roles of serum ferritin as a measure of both iron status and inflammation. We suggest benefits of a lower range of serum ferritin as has occurred for total serum cholesterol and fasting blood glucose levels. Observations during a prospective randomized study using phlebotomy in patients with peripheral arterial disease offered unique insights into dual roles of serum ferritin both as an iron status marker and acute phase reactant. Robust positive associations between serum ferritin, interleukin 6 [IL-6], tissue necrosis factor-alpha, and high sensitivity C-reactive protein were discovered. Elevated serum ferritin and IL-6 levels associated with increased mortality and with reduced mortality at ferritin levels <100 ng mL-1. Epidemiologic studies demonstrate similar outcomes. Extremely elevated ferritin and IL-6 levels also occur in individuals with high mortality due to SARS-CoV-2 infection. Disordered iron metabolism reflected by a high range of serum ferritin level signals disease severity and outcomes. Based upon experimental and epidemiologic data, we suggest testing the hypotheses that optimal ferritin levels for cardiovascular mortality reduction range from 20 to 100 ng mL-1 with % transferrin levels from 20 to 50%, to ensure adequate iron status and that ferritin levels above 194 ng mL-1 associate with all-cause mortality in population cohorts.en_US
dc.description.urihttps://doi.org/10.1093/mtomcs/mfab030en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofMetallomics : integrated biometal scienceen_US
dc.rightsPublished by Oxford University Press 2021.en_US
dc.subjectCovid-19en_US
dc.subjectatherosclerosisen_US
dc.subjectferritinen_US
dc.subjecthyperferritinemic syndromesen_US
dc.subjectinflammatory cytokinesen_US
dc.subjectiron metabolismen_US
dc.titleOptimal serum ferritin level range: iron status measure and inflammatory biomarkeren_US
dc.typeArticleen_US
dc.identifier.doi10.1093/mtomcs/mfab030
dc.identifier.pmid34048587
dc.source.volume13
dc.source.issue6
dc.source.countryEngland


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