• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Characterization of beta-cyclodextrin for direct compression tableting.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Find Full text
    Author
    Pande, Girish Shridhar
    Advisor
    Shangraw, Ralph F., Ph.D.
    Date
    1993
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    A physically modified beta-cyclodextrin sample (BCD-DC) was characterized as a filler-binder for direct compression tableting by comparing it to a commercially available beta-cyclodextrin product (Kleptose{dollar}\sp\circler{dollar}) and commonly used direct compression filler-binders such as microcrystalline cellulose (MCC), spray dried lactose (SDL) and dicalcium phosphate (DCP). Aspects examined included the compactibility of beta-cyclodextrin, deformation mechanism of beta-cyclodextrin, the role of moisture in the compactibility of beta-cyclodextrin and the effect of beta-cyclodextrin on the dissolution of poorly soluble actives. The physical modification of beta-cyclodextrin resulted in a considerable improvement in its properties as a direct compression filler-binder. The compactibility of the BCD-DC sample was comparable to that of MCC and significantly better than Kleptose{dollar}\sp\circler{dollar}, SDL and DCP. BCD-DC possessed adequate flow for direct compression using a rotary press. The primary deformation mechanism of BCD was found to be plastic flow. Scanning electron photomicrographs of BCD-DC showed the presence of cracks and laminations which result in the higher surface area of BCD-DC relative to Kleptose{dollar}\sp\circler{dollar}. These differences in the external particle characteristics are primarily responsible for the greater compactibility of BCD-DC. Moisture plays a critical role in the compactibility of beta-cyclodextrin. The moisture sorption-desorption isotherms revealed considerable hysteresis. The complete removal of water results in a loss of the compactibility of beta-cyclodextrin. There appears to be an optimal level of moisture for maximum compactibility. The dissolution studies using direct compression formulations of spironolactone revealed that dissolution rate of the drug was significantly faster from a formulation containing beta-cyclodextrin as a filler than from those containing MCC, SDL, or DCP as the fillers. This can be attributed to the increased solubility of spironolactone due to complexation with beta-cyclodextrin. The beta-cyclodextrin formulation was more compactible than the SDL and DCP formulations but less than the MCC formulation. For the medroxyprogesterone acetate formulations, dissolution rate was fastest from the formulation containing SDL as the filler followed by the beta-cyclodextrin formulation. This was attributed to the higher solubility of SDL and lack of interaction with beta-cyclodextrin. beta-Cyclodextrin has been characterized more than any other modern tablet excipient prior to commercialization and has considerable promise as a direct compression filler-binder.
    Description
    University of Maryland, Baltimore. Pharmaceutical Sciences. Ph.D. 1993
    Keyword
    Chemistry, Pharmaceutical
    Health Sciences, Pharmacy
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/1603
    Collections
    Theses and Dissertations All Schools
    Theses and Dissertations School of Pharmacy

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.