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dc.contributor.authorHuang, Mei Zhen
dc.contributor.authorYoon, Yong-Soon
dc.contributor.authorYang, Jisu
dc.contributor.authorYang, Chung-Yong
dc.contributor.authorZhang, Li-Qun
dc.date.accessioned2021-06-15T16:37:47Z
dc.date.available2021-06-15T16:37:47Z
dc.date.issued2021-05-24
dc.identifier.urihttp://hdl.handle.net/10713/16010
dc.description.abstractObjects: To evaluate the feasibility and effectiveness of in-bed wearable elbow robot training for motor recovery in patients with early and late subacute stroke. Methods: Eleven in-patient stroke survivors (male/female: 7/4, age: 50.7 ± 10.6 years, post-stroke duration: 2.6 ± 1.9 months) received 15 sessions of training over about 4 weeks of hospital stay. During each hourly training, participants received passive stretching and active movement training with motivating games using a wearable elbow rehabilitation robot. Isometric maximum muscle strength (MVC) of elbow flexors and extensors was evaluated using the robot at the beginning and end of each training session. Clinical measures including Fugl-Meyer Assessment of upper extremity (FMA-UE), Motricity Index (MI) for upper extremities, Modified Ashworth Scale (MAS) were measured at baseline, after the 4-week training program, and at a 1-month follow-up. The muscle strength recovery curve over the training period was characterized as a logarithmic learning curve with three parameters (i.e., initial muscle strength, rate of improvement, and number of the training session). Results: At the baseline, participants had moderate to severe upper limb motor impairment {FMA-UE [median (interquartile range)]: 28 (18-45)} and mild spasticity in elbow flexors {MAS [median (interquartile range)]: 0 (0-1)}. After about 4 weeks of training, significant improvements were observed in FMA-UE (p = 0.003) and MI (p = 0.005), and the improvements were sustained at the follow-up. The elbow flexors MVC significantly increased by 1.93 Nm (95% CI: 0.93 to 2.93 Nm, p = 0.017) and the elbow extensor MVC increased by 0.68 Nm (95% CI: 0.05 to 1.98 Nm, p = 0.036). Muscle strength recovery curve showed that patients with severe upper limb motor impairment had a greater improvement rate in elbow flexor strength than those with moderate motor impairment. Conclusion: In-bed wearable elbow robotic rehabilitation is feasible and effective in improving biomechanical and clinical outcomes for early and late subacute stroke in-patients. Results from the pilot study suggested that patients with severe upper limb motor impairment may benefit more from the robot training compared to those with moderate impairment.en_US
dc.description.urihttps://doi.org/10.3389/fnhum.2021.669059en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Human Neuroscienceen_US
dc.rightsCopyright © 2021 Huang, Yoon, Yang, Yang and Zhang.en_US
dc.subjectrecovery time courseen_US
dc.subjectroboten_US
dc.subjectstroke rehabilitationen_US
dc.subjectsubacute strokeen_US
dc.subjectupper limbsen_US
dc.titleIn-Bed Sensorimotor Rehabilitation in Early and Late Subacute Stroke Using a Wearable Elbow Robot: A Pilot Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fnhum.2021.669059
dc.identifier.pmid34108868
dc.source.volume15
dc.source.beginpage669059
dc.source.endpage
dc.source.countrySwitzerland


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