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dc.contributor.authorSong, Bing
dc.contributor.authorFu, Haijun
dc.contributor.authorLiu, Jianwei
dc.contributor.authorRen, Ke
dc.contributor.authorWeir, Michael D
dc.contributor.authorSchneider, Abraham
dc.contributor.authorWang, Ping
dc.contributor.authorSong, Yang
dc.contributor.authorZhao, Liang
dc.contributor.authorXu, Huakun
dc.date.accessioned2021-06-15T15:54:42Z
dc.date.available2021-06-15T15:54:42Z
dc.date.issued2021-05-03
dc.identifier.urihttp://hdl.handle.net/10713/16007
dc.description.abstractHuman induced pluripotent stem cells (hiPSCs) are exciting for regenerative medicine due to their multi-potent differentiation. SB431542 bioactive molecule can activate bone morphogenetic protein-signalling in osteoblasts. The objectives were to: (1) develop a novel injectable calcium phosphate cement (CPC)-SB431542 scaffold for dental/craniofacial bone engineering; and (2) investigate cell proliferation and osteo-differentiation of hiPSC-derived mesenchymal stem cells (hiPSC-MSCs) on CPC-SB431542 scaffold. Three groups were tested: CPC control; CPC with SB431542 inside CPC (CPCSM); CPC with SB431542 in osteogenic medium (CPC+SMM). SB431542 in CPC promoted stem cell proliferation and viability. hiPSC-MSCs differentiated into osteogenic lineage and synthesized bone minerals. CPC with SB431542 showed much greater osteo-expressions and more bone minerals than those without SB431542. In conclusion, hiPSC-MSCs on CPC scaffold containing SB431542 showed excellent osteo-differentiation and bone mineral synthesis for the first time. CPC was a suitable scaffold for delivering stem cells and SB431542 to promote bone regeneration in dental/craniofacial applications.en_US
dc.description.urihttps://doi.org/10.4012/dmj.2019-263en_US
dc.language.isoenen_US
dc.publisherNihon Shika Riko Gakkai/Japanese Society for Dental Materials and Devicesen_US
dc.relation.ispartofDental Materials Journalen_US
dc.subjectBone tissue engineeringen_US
dc.subjectCalcium phosphate cementen_US
dc.subjectInduced-pluripotent stem cellsen_US
dc.subjectOsteogenic differentiationen_US
dc.subjectSmall molecule SB431542en_US
dc.titleBioactive small molecules in calcium phosphate scaffold enhanced osteogenic differentiation of human induced pluripotent stem cellsen_US
dc.typeArticleen_US
dc.identifier.doi10.4012/dmj.2019-263
dc.identifier.pmid33814531
dc.source.volume40
dc.source.issue3
dc.source.beginpage615
dc.source.endpage624
dc.source.countryJapan


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