Prevalence and seroprevalence of Plasmodium infection in Myanmar reveals highly heterogeneous transmission and a large hidden reservoir of infection
AuthorEdwards, Hannah M
Zegers de Beyl, Celine
Myint Oo, Moe
Thwe Han, Kay
Myaing Nyunt, Myaing
PublisherPublic Library of Science
MetadataShow full item record
AbstractMalaria incidence in Myanmar has significantly reduced over recent years, however, completeness and timeliness of incidence data remain a challenge. The first ever nationwide malaria infection and seroprevalence survey was conducted in Myanmar in 2015 to better understand malaria epidemiology and highlight gaps in Annual Parasite Index (API) data. The survey was a cross-sectional two-stage stratified cluster-randomised household survey conducted from July-October 2015. Blood samples were collected from household members for ultra-sensitive PCR and serology testing for P. falciparum and P. vivax. Data was gathered on demography and a priori risk factors of participants. Data was analysed nationally and within each of four domains defined by API data. Prevalence and seroprevalence of malaria were 0.74% and 16.01% nationwide, respectively. Prevalent infection was primarily asymptomatic P. vivax, while P. falciparum was predominant in serology. There was large heterogeneity between villages and by domain. At the township level, API showed moderate correlation with P. falciparum seroprevalence. Risk factors for infection included socioeconomic status, domain, and household ownership of nets. Three K13 P. falciparum mutants were found in highly prevalent villages. There results highlight high heterogeneity of both P. falciparum and P. vivax transmission between villages, accentuated by a large hidden reservoir of asymptomatic P. vivax infection not captured by incidence data, and representing challenges for malaria elimination. Village-level surveillance and stratification to guide interventions to suit local context and targeting of transmission foci with evidence of drug resistance would aid elimination efforts.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/15996
- Malaria epidemiology in central Myanmar: identification of a multi-species asymptomatic reservoir of infection.
- Authors: Ghinai I, Cook J, Hla TT, Htet HM, Hall T, Lubis IN, Ghinai R, Hesketh T, Naung Y, Lwin MM, Latt TS, Heymann DL, Sutherland CJ, Drakeley C, Field N
- Issue date: 2017 Jan 5
- Submicroscopic Plasmodium prevalence in relation to malaria incidence in 20 villages in western Cambodia.
- Authors: Tripura R, Peto TJ, Veugen CC, Nguon C, Davoeung C, James N, Dhorda M, Maude RJ, Duanguppama J, Patumrat K, Imwong M, von Seidlein L, Grobusch MP, White NJ, Dondorp AM
- Issue date: 2017 Jan 31
- Geographical heterogeneity in prevalence of subclinical malaria infections at sentinel endemic sites of Myanmar.
- Authors: Liu Z, Soe TN, Zhao Y, Than A, Cho C, Aung PL, Li Y, Wang L, Yang H, Li X, Li D, Peng Z, Wang J, Li Y, Yang Z, Zhou H, Wang Q, Kyaw MP, Cao Y, Cui L
- Issue date: 2019 Feb 18
- Plasmodium malariae and Plasmodium ovale infections in the China-Myanmar border area.
- Authors: Li P, Zhao Z, Xing H, Li W, Zhu X, Cao Y, Yang Z, Sattabongkot J, Yan G, Fan Q, Cui L
- Issue date: 2016 Nov 15
- A novel method for extracting nucleic acids from dried blood spots for ultrasensitive detection of low-density Plasmodium falciparum and Plasmodium vivax infections.
- Authors: Zainabadi K, Adams M, Han ZY, Lwin HW, Han KT, Ouattara A, Thura S, Plowe CV, Nyunt MM
- Issue date: 2017 Sep 18