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dc.contributor.authorBhargava, Aditi
dc.contributor.authorArnold, Arthur P
dc.contributor.authorBangasser, Debra A
dc.contributor.authorDenton, Kate M
dc.contributor.authorGupta, Arpana
dc.contributor.authorHilliard Krause, Lucinda M
dc.contributor.authorMayer, Emeran A
dc.contributor.authorMcCarthy, Margaret
dc.contributor.authorMiller, Walter L
dc.contributor.authorRaznahan, Armin
dc.contributor.authorVerma, Ragini
dc.date.accessioned2021-06-10T13:09:27Z
dc.date.available2021-06-10T13:09:27Z
dc.date.issued2021-03-11
dc.identifier.urihttp://hdl.handle.net/10713/15979
dc.description.abstractIn May 2014, the National Institutes of Health (NIH) stated its intent to "require applicants to consider sex as a biological variable (SABV) in the design and analysis of NIH-funded research involving animals and cells." Since then, proposed research plans that include animals routinely state that both sexes/genders will be used; however, in many instances, researchers and reviewers are at a loss about the issue of sex differences. Moreover, the terms sex and gender are used interchangeably by many researchers, further complicating the issue. In addition, the sex or gender of the researcher might influence study outcomes, especially those concerning behavioral studies, in both animals and humans. The act of observation may change the outcome (the "observer effect") and any experimental manipulation, no matter how well-controlled, is subject to it. This is nowhere more applicable than in physiology and behavior. The sex of established cultured cell lines is another issue, in addition to aneuploidy; chromosomal numbers can change as cells are passaged. Additionally, culture medium contains steroids, growth hormone, and insulin that might influence expression of various genes. These issues often are not taken into account, determined, or even considered. Issues pertaining to the "sex" of cultured cells are beyond the scope of this Statement. However, we will discuss the factors that influence sex and gender in both basic research (that using animal models) and clinical research (that involving human subjects), as well as in some areas of science where sex differences are routinely studied. Sex differences in baseline physiology and associated mechanisms form the foundation for understanding sex differences in diseases pathology, treatments, and outcomes. The purpose of this Statement is to highlight lessons learned, caveats, and what to consider when evaluating data pertaining to sex differences, using 3 areas of research as examples; it is not intended to serve as a guideline for research design. © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.en_US
dc.description.urihttps://doi.org/10.1210/endrev/bnaa034en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofEndocrine Reviewsen_US
dc.rights© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.en_US
dc.subjectbrain-guten_US
dc.subjectcardiovascular diseaseen_US
dc.subjectchromosome complementen_US
dc.subjectgenderen_US
dc.subjectsex differencesen_US
dc.subjectsteroid hormonesen_US
dc.titleConsidering Sex as a Biological Variable in Basic and Clinical Studies: An Endocrine Society Scientific Statementen_US
dc.typeArticleen_US
dc.identifier.doi10.1210/endrev/bnaa034
dc.identifier.pmid33704446
dc.source.volume42
dc.source.issue3
dc.source.beginpage219
dc.source.endpage258
dc.source.countryUnited States


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