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dc.contributor.authorOberstaller, Jenna
dc.contributor.authorZoungrana, Linda
dc.contributor.authorBannerman, Carl D
dc.contributor.authorJahangiri, Samira
dc.contributor.authorDwivedi, Ankit
dc.contributor.authorSilva, Joana C
dc.contributor.authorAdams, John H
dc.contributor.authorTakala-Harrison, Shannon
dc.date.accessioned2021-06-10T12:31:43Z
dc.date.available2021-06-10T12:31:43Z
dc.date.issued2021-05-26
dc.identifier.urihttp://hdl.handle.net/10713/15976
dc.description.abstractResistance to antimalarial drugs, and in particular to the artemisinin derivatives and their partner drugs, threatens recent progress toward regional malaria elimination and eventual global malaria eradication. Population-level studies utilizing whole-genome sequencing approaches have facilitated the identification of regions of the parasite genome associated with both clinical and in vitro drug-resistance phenotypes. However, the biological relevance of genes identified in these analyses and the establishment of a causal relationship between genotype and phenotype requires functional characterization. Here we examined data from population genomic and transcriptomic studies in the context of data generated from recent functional studies, using a new population genetic approach designed to identify potential favored mutations within the region of a selective sweep (iSAFE). We identified several genes functioning in pathways now known to be associated with artemisinin resistance that were supported in early population genomic studies, as well as potential new drug targets/pathways for further validation and consideration for treatment of artemisinin-resistant Plasmodium falciparum. In addition, we establish the utility of iSAFE in identifying positively-selected mutations in population genomic studies, potentially accelerating the time to functional validation of candidate genes.en_US
dc.description.urihttps://doi.org/10.1016/j.ijpddr.2021.05.006en_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofInternational Journal for Parasitology. Drugs and Drug Resistanceen_US
dc.rightsCopyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.en_US
dc.subjectDrug resistanceen_US
dc.subjectFunctional genomicsen_US
dc.subjectP. falciparumen_US
dc.subjectiSAFEen_US
dc.titleIntegration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparumen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ijpddr.2021.05.006
dc.identifier.pmid34102588
dc.source.volume16
dc.source.beginpage119
dc.source.endpage128
dc.source.countryEngland


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