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dc.contributor.authorWijtenburg, S Andrea
dc.contributor.authorWang, Min
dc.contributor.authorKorenic, Stephanie A
dc.contributor.authorChen, Shuo
dc.contributor.authorBarker, Peter B
dc.contributor.authorRowland, Laura M
dc.date.accessioned2021-06-09T18:06:26Z
dc.date.available2021-06-09T18:06:26Z
dc.date.issued2021-05-19
dc.identifier.urihttp://hdl.handle.net/10713/15965
dc.description.abstractProton magnetic resonance spectroscopy (MRS) studies in schizophrenia have shown altered GABAergic, glutamatergic, and bioenergetic pathways, but if these abnormalities are brain region or illness-stage specific is largely unknown. MRS at 7T MR enables reliable quantification of multiple metabolites, including GABA, glutamate (Glu) and glutamine (Gln), from multiple brain regions within the time constraints of a clinical examination. In this study, GABA, Glu, Gln, the ratio Gln/Glu, and lactate (Lac) were quantified using 7T MRS in five brain regions in adults with schizophrenia (N = 40), first-degree relatives (N = 11), and healthy controls (N = 38). Metabolites were analyzed for differences between groups, as well as between subjects with schizophrenia with either short (<5 years, N = 19 or long (>5 years, N = 21) illness duration. For analyses between the three groups, there were significant glutamatergic and GABAergic differences observed in the anterior cingulate, centrum semiovale, and dorsolateral prefrontal cortex. There were also significant relationships between anterior cingulate cortex, centrum semiovale, and dorsolateral prefrontal cortex and cognitive measures. There were also significant glutamatergic, GABAergic, and lactate differences between subjects with long and short illness duration in the anterior cingulate, centrum semiovale, dorsolateral prefrontal cortex, and hippocampus. Finally, negative symptom severity ratings were significantly correlated with both anterior cingulate and centrum semiovale metabolite levels. In summary, 7T MRS shows multi-region differences in GABAergic and glutamatergic metabolites between subjects with schizophrenia, first-degree relatives and healthy controls, suggesting relatively diffuse involvement that evolves with illness duration. Unmedicated first-degree relatives share some of the same metabolic characteristics as patients with a diagnosis of schizophrenia, suggesting that these differences may reflect a genetic vulnerability and are not solely due to the effects of antipsychotic interventions.en_US
dc.description.urihttps://doi.org/10.3389/fpsyt.2021.656459en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Psychiatryen_US
dc.rightsCopyright © 2021 Wijtenburg, Wang, Korenic, Chen, Barker and Rowland.en_US
dc.subject7T MRSen_US
dc.subjectGABAen_US
dc.subjectbrainen_US
dc.subjectfirst degree relativesen_US
dc.subjectglutamateen_US
dc.subjectglutamineen_US
dc.subjectmetabolismen_US
dc.subjectschizophreniaen_US
dc.titleMetabolite Alterations in Adults With Schizophrenia, First Degree Relatives, and Healthy Controls: A Multi-Region 7T MRS Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fpsyt.2021.656459
dc.identifier.pmid34093272
dc.source.volume12
dc.source.beginpage656459
dc.source.endpage
dc.source.countrySwitzerland


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