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AbstractThere are several human viruses and bacteria currently known to be associated with cancer. A common theme indicates that these microorganisms have evolved mechanisms to hamper the pathways dedicated to maintaining the integrity of genetic information, preventing apoptosis of the damaged cells and causing unwanted cellular proliferation. This eventually reduces the ability of their hosts to repair the damage(s) and eventually results in cellular transformation, cancer progression and reduced response to therapy. Our data suggest that mycoplasmas, and perhaps certain other bacteria with closely related DnaKs, may also contribute to cellular transformation and hamper certain drugs that rely on functional p53 for their anti-cancer activity. Understanding the precise molecular mechanisms is important for cancer prevention and for the development of both new anti-cancer drugs and for improving the efficacy of existing therapies.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/15959
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- Viral manipulation of DNA repair and cell cycle checkpoints.
- Authors: Chaurushiya MS, Weitzman MD
- Issue date: 2009 Sep 2
- The real 'hot zone'.
- Authors: Cowley G
- Issue date: 2000 Nov 27