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    Viruses and Bacteria Associated with Cancer: An Overview

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    Author
    Zella, Davide
    Gallo, Robert C
    Date
    2021-05-31
    Journal
    Viruses
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/v13061039
    Abstract
    There are several human viruses and bacteria currently known to be associated with cancer. A common theme indicates that these microorganisms have evolved mechanisms to hamper the pathways dedicated to maintaining the integrity of genetic information, preventing apoptosis of the damaged cells and causing unwanted cellular proliferation. This eventually reduces the ability of their hosts to repair the damage(s) and eventually results in cellular transformation, cancer progression and reduced response to therapy. Our data suggest that mycoplasmas, and perhaps certain other bacteria with closely related DnaKs, may also contribute to cellular transformation and hamper certain drugs that rely on functional p53 for their anti-cancer activity. Understanding the precise molecular mechanisms is important for cancer prevention and for the development of both new anti-cancer drugs and for improving the efficacy of existing therapies.
    Keyword
    DnaK
    anti-cancer therapy
    bacteria
    cancer progression
    carcinogenesis
    viruses
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15959
    ae974a485f413a2113503eed53cd6c53
    10.3390/v13061039
    Scopus Count
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