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    Targeting Natural Killer T Cells in Solid Malignancies

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    Author
    Ingram, Zewde
    Madan, Shriya
    Merchant, Jenoy
    Carter, Zakiya
    Gordon, Zen
    Carey, Gregory
    Webb, Tonya J
    Date
    2021-05-27
    Journal
    Cells
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/cells10061329
    Abstract
    Natural killer T (NKT) cells are a unique subset of lymphocytes that recognize lipid antigens in the context of the non-classical class I MHC molecule, CD1d, and serve as a link between the innate and adaptive immune system through their expeditious release of cytokines. Whereas NKT have well-established roles in mitigating a number of human diseases, herein, we focus on their role in cancer. NKT cells have been shown to directly and indirectly mediate anti-tumor immunity and manipulating their effector functions can have therapeutic significances in treatment of cancer. In this review, we highlight several therapeutic strategies that have been used to harness the effector functions of NKT cells to target different types of solid tumors. We also discuss several barriers to the successful utilization of NKT cells and summarize effective strategies being developed to harness the unique strengths of this potent population of T cells. Collectively, studies investigating the therapeutic potential of NKT cells serve not only to advance our understanding of this powerful immune cell subset, but also pave the way for future treatments focused on the modulation of NKT cell responses to enhance cancer immunotherapy.
    Keyword
    CD1d
    NKT cells
    cancer immunotherapy
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15957
    ae974a485f413a2113503eed53cd6c53
    10.3390/cells10061329
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