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dc.contributor.authorMagdy, Galal
dc.contributor.authorBelal, Fathalla
dc.contributor.authorAbdel-Megied, Ahmed M.
dc.contributor.authorAbdel Hakiem, Ahmed F.
dc.date.accessioned2021-06-07T16:36:22Z
dc.date.available2021-06-07T16:36:22Z
dc.date.issued2021-05-26
dc.identifier.urihttp://hdl.handle.net/10713/15934
dc.description.abstractTwo green, simple and sensitive synchronous spectrofluorimetric methods were developed for the first time for the simultaneous estimation of febuxostat (FEB) and ibuprofen (IBU). Method I is constant-wavelength synchronous spectrofluorimetry where FEB and IBU were recorded at 329 and 258 nm, respectively, using Δλ of 40 nm. Method II is constant-energy synchronous spectrofluorimetry using a wavenumber interval of -4000 cm-1. All measurements were carried out in a borate buffer of pH 7 and distilled water for dilution which increased the methods' greenness. The two methods were rectilinear over concentration ranges of 30.0-700.0 ng ml-1 and 0.5-9.0 µg ml-1 in the first method and 20.0-500.0 ng ml-1 and 0.1-8.0 µg ml-1 in the second method for FEB and IBU, respectively. High sensitivity was attained for the two drugs with limits of quantitations (LODs) down to 0.41 and 5.51 ng ml-1 in the first method and 0.25 and 3.32 ng ml-1 in the second method for FEB and IBU, respectively. Recovery percentages were in the range of 97.3-101.9% after extraction from spiked human plasma samples, demonstrating high bioanalytical applicability. The two methods were further applied to tablet dosage forms with good recovery results. The methods' greenness was assessed according to the analytical Eco-Scale and Green Analytical Procedure Index guidelines.en_US
dc.description.urihttps://doi.org/10.1098/rsos.210354en_US
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc8150019/en_US
dc.language.isoenen_US
dc.publisherThe Royal Societyen_US
dc.relation.ispartofRoyal Society Open Scienceen_US
dc.rights.urihttps://royalsociety.org/journals/ethics-policies/data-sharing-mining/
dc.subjectfebuxostaten_US
dc.subjectgreen chemistryen_US
dc.subjecthuman plasmaen_US
dc.subjectibuprofenen_US
dc.subjectsynchronous spectrofluorimetryen_US
dc.titleTwo different synchronous spectrofluorimetric approaches for simultaneous determination of febuxostat and ibuprofenen_US
dc.typeArticleen_US
dc.identifier.doi10.1098/rsos.210354
dc.identifier.pmid34084553
dc.source.volume8
dc.source.issue5
dc.source.beginpage210354


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