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dc.contributor.authorChung, Man-Kyo
dc.contributor.authorWang, Sheng
dc.contributor.authorOh, Se-Lim
dc.contributor.authorKim, Yu Shin
dc.date.accessioned2021-06-07T13:44:46Z
dc.date.available2021-06-07T13:44:46Z
dc.date.issued2021-05-28
dc.identifier.urihttp://hdl.handle.net/10713/15919
dc.description.abstractThe oral cavity is a portal into the digestive system, which exhibits unique sensory properties. Like facial skin, the oral mucosa needs to be exquisitely sensitive and selective, in order to detect harmful toxins versus edible food. Chemosensation and somatosensation by multiple receptors, including transient receptor potential channels, are well-developed to meet these needs. In contrast to facial skin, however, the oral mucosa rarely exhibits itch responses. Like the gut, the oral cavity performs mechanical and chemical digestion. Therefore, the oral mucosa needs to be insensitive, to some degree, in order to endure noxious irritation. Persistent pain from the oral mucosa is often due to ulcers, involving both tissue injury and infection. Trigeminal nerve injury and trigeminal neuralgia produce intractable pain in the orofacial skin and the oral mucosa, through mechanisms distinct from those seen in the spinal area, which is particularly difficult to predict or treat. The diagnosis and treatment of idiopathic chronic pain, such as atypical odontalgia (idiopathic painful trigeminal neuropathy or post-traumatic trigeminal neuropathy) and burning mouth syndrome, remain especially challenging. The central integration of gustatory inputs might modulate chronic oral and facial pain. A lack of pain in chronic inflammation inside the oral cavity, such as chronic periodontitis, involves the specialized functioning of oral bacteria. A more detailed understanding of the unique neurobiology of pain from the orofacial skin and the oral mucosa should help us develop novel methods for better treating persistent orofacial pain. © 2021 by the authors.en_US
dc.description.urihttps://doi.org/10.3390/ijms22115810en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.subjectchronic painen_US
dc.subjectmucosa painen_US
dc.subjectorofacial painen_US
dc.titleAcute and Chronic Pain from Facial Skin and Oral Mucosa: Unique Neurobiology and Challenging Treatmenten_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms22115810
dc.identifier.pmid34071720
dc.source.volume22
dc.source.issue11
dc.source.countrySwitzerland


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