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dc.contributor.authorWang, Qinchuan
dc.contributor.authorHernández-Ochoa, Erick O
dc.contributor.authorViswanathan, Meera C
dc.contributor.authorBlum, Ian D
dc.contributor.authorDo, Danh C
dc.contributor.authorGranger, Jonathan M
dc.contributor.authorMurphy, Kevin R
dc.contributor.authorWei, An-Chi
dc.contributor.authorAja, Susan
dc.contributor.authorLiu, Naili
dc.contributor.authorAntonescu, Corina M
dc.contributor.authorFlorea, Liliana D
dc.contributor.authorTalbot, C Conover
dc.contributor.authorMohr, David
dc.contributor.authorWagner, Kathryn R
dc.contributor.authorRegot, Sergi
dc.contributor.authorLovering, Richard M
dc.contributor.authorGao, Peisong
dc.contributor.authorBianchet, Mario A
dc.contributor.authorWu, Mark N
dc.contributor.authorCammarato, Anthony
dc.contributor.authorSchneider, Martin F
dc.contributor.authorBever, Gabriel S
dc.contributor.authorAnderson, Mark E
dc.date.accessioned2021-06-03T14:24:51Z
dc.date.available2021-06-03T14:24:51Z
dc.date.issued2021-05-26
dc.identifier.urihttp://hdl.handle.net/10713/15913
dc.description.abstractAntagonistic pleiotropy is a foundational theory that predicts aging-related diseases are the result of evolved genetic traits conferring advantages early in life. Here we examine CaMKII, a pluripotent signaling molecule that contributes to common aging-related diseases, and find that its activation by reactive oxygen species (ROS) was acquired more than half-a-billion years ago along the vertebrate stem lineage. Functional experiments using genetically engineered mice and flies reveal ancestral vertebrates were poised to benefit from the union of ROS and CaMKII, which conferred physiological advantage by allowing ROS to increase intracellular Ca2+ and activate transcriptional programs important for exercise and immunity. Enhanced sensitivity to the adverse effects of ROS in diseases and aging is thus a trade-off for positive traits that facilitated the early and continued evolutionary success of vertebrates.en_US
dc.description.urihttps://doi.org/10.1038/s41467-021-23549-3en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNature Communicationsen_US
dc.subjectCaMKIIen_US
dc.subjectage-related diseaseen_US
dc.subject.meshCalcium-Calmodulin-Dependent Protein Kinase Type 2en_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshReactive Oxygen Species--adverse effectsen_US
dc.titleCaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolutionen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41467-021-23549-3
dc.identifier.pmid34039988
dc.source.volume12
dc.source.issue1
dc.source.beginpage3175
dc.source.endpage
dc.source.countryEngland


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