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dc.contributor.authorShah, Zalak
dc.contributor.authorNaung, Myo T
dc.contributor.authorMoser, Kara A
dc.contributor.authorAdams, Matthew
dc.contributor.authorBuchwald, Andrea G
dc.contributor.authorDwivedi, Ankit
dc.contributor.authorOuattara, Amed
dc.contributor.authorSeydel, Karl B
dc.contributor.authorMathanga, Don P
dc.contributor.authorBarry, Alyssa E
dc.contributor.authorSerre, David
dc.contributor.authorLaufer, Miriam K
dc.contributor.authorSilva, Joana C
dc.contributor.authorTakala-Harrison, Shannon
dc.date.accessioned2021-06-03T13:12:41Z
dc.date.available2021-06-03T13:12:41Z
dc.date.issued2021-05-25
dc.identifier.urihttp://hdl.handle.net/10713/15907
dc.description.abstractIndividuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals followed longitudinally. Here we expand this approach by analyzing genome-wide polymorphisms using whole genome sequence data from 140 parasite isolates representing malaria cases from a longitudinal study in Malawi and identify 25 genes that encode possible targets of naturally acquired immunity that should be validated immunologically and further characterized for their potential as vaccine candidates.en_US
dc.description.urihttps://doi.org/10.1371/journal.pgen.1009576en_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS Geneticsen_US
dc.subjectgenome-wide polymorphismsen_US
dc.subject.meshMalaria, Falciparum--immunologyen_US
dc.subject.meshPlasmodium falciparum--geneticsen_US
dc.subject.meshWhole Genome Sequencingen_US
dc.subject.meshMalawien_US
dc.titleWhole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malariaen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pgen.1009576
dc.identifier.pmid34033654
dc.source.volume17
dc.source.issue5
dc.source.beginpagee1009576
dc.source.endpage
dc.source.countryUnited States


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