Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria
Author
Shah, Zalak
Naung, Myo T
Moser, Kara A
Adams, Matthew
Buchwald, Andrea G
Dwivedi, Ankit
Ouattara, Amed
Seydel, Karl B
Mathanga, Don P
Barry, Alyssa E
Serre, David
Laufer, Miriam K
Silva, Joana C
Takala-Harrison, Shannon
Date
2021-05-25Journal
PLoS GeneticsPublisher
Public Library of ScienceType
Article
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Show full item recordAbstract
Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals followed longitudinally. Here we expand this approach by analyzing genome-wide polymorphisms using whole genome sequence data from 140 parasite isolates representing malaria cases from a longitudinal study in Malawi and identify 25 genes that encode possible targets of naturally acquired immunity that should be validated immunologically and further characterized for their potential as vaccine candidates.Keyword
genome-wide polymorphismsMalaria, Falciparum--immunology
Plasmodium falciparum--genetics
Whole Genome Sequencing
Malawi
Identifier to cite or link to this item
http://hdl.handle.net/10713/15907ae974a485f413a2113503eed53cd6c53
10.1371/journal.pgen.1009576
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