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    Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria

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    Author
    Shah, Zalak cc
    Naung, Myo T
    Moser, Kara A
    Adams, Matthew
    Buchwald, Andrea G
    Dwivedi, Ankit
    Ouattara, Amed
    Seydel, Karl B
    Mathanga, Don P
    Barry, Alyssa E
    Serre, David
    Laufer, Miriam K
    Silva, Joana C
    Takala-Harrison, Shannon
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    Date
    2021-05-25
    Journal
    PLoS Genetics
    Publisher
    Public Library of Science
    Type
    Article
    
    Metadata
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    See at
    https://doi.org/10.1371/journal.pgen.1009576
    Abstract
    Individuals acquire immunity to clinical malaria after repeated Plasmodium falciparum infections. Immunity to disease is thought to reflect the acquisition of a repertoire of responses to multiple alleles in diverse parasite antigens. In previous studies, we identified polymorphic sites within individual antigens that are associated with parasite immune evasion by examining antigen allele dynamics in individuals followed longitudinally. Here we expand this approach by analyzing genome-wide polymorphisms using whole genome sequence data from 140 parasite isolates representing malaria cases from a longitudinal study in Malawi and identify 25 genes that encode possible targets of naturally acquired immunity that should be validated immunologically and further characterized for their potential as vaccine candidates.
    Keyword
    genome-wide polymorphisms
    Malaria, Falciparum--immunology
    Plasmodium falciparum--genetics
    Whole Genome Sequencing
    Malawi
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15907
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pgen.1009576
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