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dc.contributor.authorWu, Angela
dc.contributor.authorBurrowes, Shana
dc.contributor.authorZisman, Erin
dc.contributor.authorBrown, Todd Tarquin
dc.contributor.authorBagchi, Shashwatee
dc.date.accessioned2021-06-03T12:58:27Z
dc.date.available2021-06-03T12:58:27Z
dc.date.issued2021-05en_US
dc.identifier.urihttp://hdl.handle.net/10713/15906
dc.description.abstractInfections with hepatitis C virus (HCV) represent a substantial national and international public health burden. HCV has been associated with numerous extrahepatic conditions and can lead to metabolic derangements that are associated with atherosclerosis and cardiovascular disease. We investigated whether HCV infection is associated with an increased number of acute coronary syndrome (ACS) events among hospitalized patients in an inner-city tertiary hospital.We performed a matched (age, sex, and race/ethnicity) case-control study on patients at least 18 years old admitted to inpatient medical and cardiac services at the University of Maryland Medical Center from 2015 through 2018. The primary outcome was ACS and the primary exposure was HCV infection. Covariates of interest included: alcohol use, tobacco use, illicit drug use, hypertension, diabetes mellitus, human immunodeficiency virus infection, body mass index, dyslipidemia, and family history of coronary heart disease. Covariates with significant associations with both exposure and outcome in bivariate analyses were included in the multivariable analyses of the final adjusted model.There were 1555 cases and 3110 controls included in the final sample. Almost 2% of cases and 2.4% of controls were HCV infected. In adjusted models, there was no significant association found between experiencing an ACS event in those with HCV infection compared to those without HCV infection (odds ratio 0.71, 95% confidence interval 0.45-1.11).We found no significant association between HCV infection and ACS in our study population. However, given the mixed existing literature, the association between HCV and ACS warrants further investigation in future prospective cohort and/or interventional studies.en_US
dc.description.urihttps://doi.org/10.1097/MD.0000000000026033en_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Healthen_US
dc.relation.ispartofMedicineen_US
dc.rightsCopyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.en_US
dc.subjectacute coronary syndromeen_US
dc.subjectatherosclerosisen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectcoronary heart diseaseen_US
dc.subjecthepatitis Cen_US
dc.titleAssociation of hepatitis C infection and acute coronary syndrome: A case-control studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1097/MD.0000000000026033
dc.identifier.pmid34032724
dc.source.volume100
dc.source.issue21
dc.source.beginpagee26033
dc.source.endpage
dc.source.countryUnited States


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