Hong, L Elliot
Saeedi, Osamah J
JournalTranslational Vision Science & Technology
PublisherAssociation for Research in Vision and Ophthalmology, Inc.
MetadataShow full item record
AbstractPurpose: We evaluated the patient-control differences and predictive value of the retina as potential biomarkers for schizophrenia. Methods: The institutional study included both eyes of 58 schizophrenia spectrum disorder (SSD) patients (age 37.2 ± 12.3 years) and 35 controls (age 41.1 ± 15.2 years). Retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer, outer retinal photoreceptor complex, and total macula thicknesses were measured by optical coherence tomography (OCT). Anterior segment parameters including central corneal thickness, anterior chamber depth, and axial length were measured to rule out confounds on the retinal measures. Results: The peripapillary RNFL was overall significantly thinner in SSD relative to controls (F = 3.97, P = 0.049), most pronounced in the temporal (5.2 µm difference, F = 6.95, P = 0.010) and inferior quadrants (12.1 µm difference, F = 7.32, P = 0.009). There were no significant group differences in thickness for the macular RNFL, ganglion, or photoreceptor cell related measures (P > 0.05). Peripapillary RNFL, central macula, and outer photoreceptor complex thicknesses were together able to classify SSD patients with 80% sensitivity and 71% specificity; area under the curve = 0.82 (95% confidence interval, 0.75-0.88). Conclusions: SSD patients exhibited significant RNFL thinning relative to controls. Notably, retinal thickness measures including both peripapillary and macular data exhibited improved diagnostic accuracy for SSD as compared to these regions alone. Translational relevance: This is the first study to evaluate the predictive value of both the inner and outer retina in SSD. OCT retinal thickness measures including peripapillary data in conjunction with macular data may provide an informative, noninvasive in vivo ocular biomarker for schizophrenia.
Keywordschizophrenia spectrum disorders
optical coherence tomography
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/15905
- Evaluation of the peripapillary retinal nerve fiber layer and ganglion cell-inner plexiform layer measurements in patients with iron deficiency anemia with optical coherence tomography.
- Authors: Acir NO, Dadaci Z, Cetiner F, Yildiz M, Alptekin H, Borazan M
- Issue date: 2016
- Peripapillary retinal nerve fiber layer thickness in sickle-cell hemoglobinopathies using spectral-domain optical coherence tomography.
- Authors: Chow CC, Shah RJ, Lim JI, Chau FY, Hallak JA, Vajaranant TS
- Issue date: 2013 Mar
- Normal Reference Ranges of Optical Coherence Tomography Parameters in Children.
- Authors: Krumova S, Sivkova N, Marinov V, Koleva-Georgieva D, Voynikova D
- Issue date: 2020 Jun 30
- Ganglion cell-inner plexiform layer and retinal nerve fibre layer changes within the macula in retinitis pigmentosa: a spectral domain optical coherence tomography study.
- Authors: Yoon CK, Yu HG
- Issue date: 2018 Mar
- THE THICKNESSES OF CHOROID, MACULAR SEGMENTS, PERIPAPILLARY RETINAL NERVE FIBER LAYER, AND RETINAL VASCULAR CALIBER IN HIV-1-INFECTED PATIENTS WITHOUT INFECTIOUS RETINITIS.
- Authors: Cetin EN, Sayin Kutlu S, Parca O, Kutlu M, Pekel G
- Issue date: 2019 Jul