• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Poor retention and care-related sex disparities among youth living with HIV in rural Mozambique

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Ahonkhai, Aima A
    Aliyu, Muktar H
    Audet, Carolyn M
    Bravo, Magdalena
    Simmons, Melynda
    Claquin, Gael
    Memiah, Peter
    Fernando, Anibal N
    Carlucci, James G
    Shepherd, Bryan E
    Van Rompaey, Sara
    Yu, Zhihong
    Gong, Wu
    Vermund, Sten H
    Wester, C William
    Show allShow less

    Date
    2021-05-21
    Journal
    PLoS ONE
    Publisher
    Public Library of Science
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1371/journal.pone.0250921
    Abstract
    BACKGROUND: There are few studies that characterize sex-related differences in HIV outcomes among adolescents and young adults (AYA) 15-24 years of age. METHODS: We conducted a retrospective cohort study among AYA who enrolled in a comprehensive HIV program in Mozambique between 2012-2016. We assessed patients by sex and pregnancy/lactation status, comparing time to combination antiretroviral therapy (ART) initiation using Cox proportional hazard models. We employed multivariable logistic regression to investigate pre- and post-ART retention. Patients were defined as 'retained pre-ART' if they attended at least 3 of 4 required visits or started ART in the 6 months after enrollment, and 'retained post-ART' if they had any ART pickup or clinical visit during the last 90 days of the one-year follow-up period. RESULTS: Of 47,702 patients in the cohort, 81% (n = 38,511) were female and 19% (n = 9,191) were male. Of the females, 57% (n = 21,770) were non-pregnant and non-lactating (NPNL) and 43% (n = 16,741) were pregnant or lactating (PL). PL (aHR 2.64, 95%CI:2.47-2.81) and NPNL females (aHR 1.36, 95%CI:1.30-1.42) were more likely to initiate ART than males. PL females had higher odds of pre-ART retention in care (aOR 3.56, 95%CI: 3.30-3.84), as did NPNL females (aOR 1.71, 95%CI: 1.62-1.81), compared to males. This was also true for retention post-ART initiation, with higher odds for both PL (aOR 1.78, 95%CI:1.63-1.94) and NPNL females (aOR 1.50, 95%CI:1.35-1.65) compared to males. CONCLUSIONS: PL females were most likely to initiate ART and remain in care post-ART in this AYA cohort, likely reflecting expansion of Option B+. Despite pregnancy and policy driven factors, we observed important sex-related disparities in this cohort. NPNL females were more likely to initiate ART and be retained in care before and after ART initiation than males. These data suggest that young males need targeted interventions to improve these important care continuum outcomes.
    Keyword
    Antiretroviral Therapy, Highly Active
    HIV
    Sex Factors
    Treatment Adherence and Compliance
    Adolescent
    Young Adult
    Mozambique
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15894
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0250921
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Validity of reported retention in antiretroviral therapy after roll-out to peripheral facilities in Mozambique: Results of a retrospective national cohort analysis.
    • Authors: Lafort Y, Couto A, Sunderbrink U, Hoek R, Shargie E, Zhao J, Viisainen K, Simwaka B
    • Issue date: 2018
    • Adolescent pregnancy at antiretroviral therapy (ART) initiation: a critical barrier to retention on ART.
    • Authors: Nuwagaba-Biribonwoha H, Kiragga AN, Yiannoutsos CT, Musick BS, Wools-Kaloustian KK, Ayaya S, Wolf H, Lugina E, Ssali J, Abrams EJ, Elul B, International epidemiology Databases to Evaluate AIDS (IeDEA) East Africa Collaboration.
    • Issue date: 2018 Sep
    • High rates of loss to follow-up during the first year of pre-antiretroviral therapy for HIV patients at sites providing pre-ART care in Nigeria, 2004-2012.
    • Authors: Agolory SG, Auld AF, Odafe S, Shiraishi RW, Dokubo EK, Swaminathan M, Dalhatu I, Onotu D, Abiri O, Debem H, Bashorun A, Ellerbrock TV
    • Issue date: 2017
    • Lessons for test and treat in an antiretroviral programme after decentralisation in Uganda: a retrospective analysis of outcomes in public healthcare facilities within the Lablite project.
    • Authors: Kiwuwa-Muyingo S, Abongomera G, Mambule I, Senjovu D, Katabira E, Kityo C, Gibb DM, Ford D, Seeley J
    • Issue date: 2020 Sep 1
    • Factors associated with long-term antiretroviral therapy attrition among adolescents in rural Uganda: a retrospective study.
    • Authors: Okoboi S, Ssali L, Yansaneh AI, Bakanda C, Birungi J, Nantume S, Okullu JL, Sharp AR, Moore DM, Kalibala S
    • Issue date: 2016
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.