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dc.contributor.authorParks, Steven Z
dc.contributor.authorGao, Tian
dc.contributor.authorJimenez Awuapura, Natalia
dc.contributor.authorAyathamattam, Joseph
dc.contributor.authorChabosseau, Pauline L
dc.contributor.authorKalvakolanu, Dhananjaya V
dc.contributor.authorValdivia, Héctor H
dc.contributor.authorRutter, Guy A
dc.contributor.authorLeclerc, Isabelle
dc.date.accessioned2021-06-01T20:07:58Z
dc.date.available2021-06-01T20:07:58Z
dc.date.issued2021-05-07
dc.identifier.urihttp://hdl.handle.net/10713/15887
dc.description.abstractSorcin is a calcium-binding protein involved in maintaining endoplasmic reticulum (ER) Ca2+ stores. We have previously shown that overexpressing sorcin under the rat insulin promoter was protective against high-fat diet-induced pancreatic beta-cell dysfunction in vivo. Activating transcription factor 6 (ATF6) is a key mediator of the unfolded protein response (UPR) that provides cellular protection during the progression of ER stress. Here, using nonexcitable HEK293 cells, we show that sorcin overexpression increased ATF6 signalling, whereas sorcin knock out caused a reduction in ATF6 transcriptional activity and increased ER stress. Altogether, our data suggest that sorcin downregulation during lipotoxic stress may prevent full ATF6 activation and a normal UPR during the progression of obesity and insulin resistance.en_US
dc.description.urihttps://doi.org/10.1002/1873-3468.14101en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofFEBS Lettersen_US
dc.rights© 2021 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.en_US
dc.subjectATF6en_US
dc.subjectER stressen_US
dc.subjectlipotoxicityen_US
dc.subjectsorcinen_US
dc.titleThe Ca2+-binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6en_US
dc.typeArticleen_US
dc.identifier.doi10.1002/1873-3468.14101
dc.identifier.pmid33960419
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryEngland


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