The Ca2+-binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6
Author
Parks, Steven ZGao, Tian
Jimenez Awuapura, Natalia
Ayathamattam, Joseph
Chabosseau, Pauline L
Kalvakolanu, Dhananjaya V
Valdivia, Héctor H
Rutter, Guy A
Leclerc, Isabelle
Date
2021-05-07Journal
FEBS LettersPublisher
Wiley-BlackwellType
Article
Metadata
Show full item recordAbstract
Sorcin is a calcium-binding protein involved in maintaining endoplasmic reticulum (ER) Ca2+ stores. We have previously shown that overexpressing sorcin under the rat insulin promoter was protective against high-fat diet-induced pancreatic beta-cell dysfunction in vivo. Activating transcription factor 6 (ATF6) is a key mediator of the unfolded protein response (UPR) that provides cellular protection during the progression of ER stress. Here, using nonexcitable HEK293 cells, we show that sorcin overexpression increased ATF6 signalling, whereas sorcin knock out caused a reduction in ATF6 transcriptional activity and increased ER stress. Altogether, our data suggest that sorcin downregulation during lipotoxic stress may prevent full ATF6 activation and a normal UPR during the progression of obesity and insulin resistance.Rights/Terms
© 2021 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.Identifier to cite or link to this item
http://hdl.handle.net/10713/15887ae974a485f413a2113503eed53cd6c53
10.1002/1873-3468.14101
Scopus Count
Collections
Related articles
- Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.
- Authors: Marmugi A, Parnis J, Chen X, Carmichael L, Hardy J, Mannan N, Marchetti P, Piemonti L, Bosco D, Johnson P, Shapiro JA, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Thorens B, Valdivia HH, Rutter GA, Leclerc I
- Issue date: 2016 Apr
- PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response.
- Authors: Gupta A, Hossain MM, Read DE, Hetz C, Samali A, Gupta S
- Issue date: 2015 Dec 17
- Calcium-independent phospholipase A2γ enhances activation of the ATF6 transcription factor during endoplasmic reticulum stress.
- Authors: Elimam H, Papillon J, Takano T, Cybulsky AV
- Issue date: 2015 Jan 30
- Mechanisms of impaired pancreatic β‑cell function in high‑fat diet‑induced obese mice: The role of endoplasmic reticulum stress.
- Authors: Yi X, Cai X, Wang S, Xiao Y
- Issue date: 2020 May
- Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress.
- Authors: Tay KH, Luan Q, Croft A, Jiang CC, Jin L, Zhang XD, Tseng HY
- Issue date: 2014 Feb