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dc.contributor.authorMcDermott, Danielle S
dc.contributor.authorMirro, Emily A
dc.contributor.authorFetrow, Kirsten
dc.contributor.authorBurdette, David E
dc.contributor.authorChen, Stephanie
dc.contributor.authorHopp, Jennifer
dc.contributor.authorMasel, Todd
dc.contributor.authorJohnson, Emily A
dc.contributor.authorElefant, Felicia M K
dc.contributor.authorLe, Scheherazade
dc.contributor.authorPatra, Sanjay E
dc.contributor.authorBrown, Mesha-Gay
dc.contributor.authorHaneef, Zulfi
dc.date.accessioned2021-06-01T19:37:04Z
dc.date.available2021-06-01T19:37:04Z
dc.date.issued2021-02-27
dc.identifier.urihttp://hdl.handle.net/10713/15886
dc.description.abstractObjective: Tuberous sclerosis complex (TSC) is a genetic disorder primarily characterized by the development of multisystem benign tumors. Epilepsy is the most common neurologic manifestation, affecting 80%-90% of TSC patients. The diffuse structural brain abnormalities and the multifocal nature of epilepsy in TSC pose diagnostic challenges when evaluating patients for epilepsy surgery. Methods: We retrospectively reviewed the safety experience and efficacy outcomes of five adult TSC patients who were treated with direct brain-responsive neurostimulation (RNS System, NeuroPace, Inc). Results: The average follow-up duration was 20 months. All five patients were responders (≥50% disabling seizure reduction) at last follow-up. The median reduction in disabling seizures was 58% at 1 year and 88% at last follow-up. Three of the five patients experienced some period of seizure freedom ranging from 3 months to over 1 year. Significance: In this small case series, we report the first safety experience and efficacy outcomes in patients with TSC-associated drug-resistant focal epilepsy treated with direct brain-responsive neurostimulation.en_US
dc.description.urihttps://doi.org/10.1002/epi4.12481en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofEpilepsia Openen_US
dc.rights© 2021 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.en_US
dc.subjectrefractory epilepsyen_US
dc.subjectresponsive neurostimulationen_US
dc.subjecttuberous sclerosis complexen_US
dc.titleBrain-Responsive Neurostimulation for the treatment of adults with epilepsy in tuberous sclerosis complex: A case seriesen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/epi4.12481
dc.identifier.pmid34033253
dc.source.countryUnited States


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