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    Brain-Responsive Neurostimulation for the treatment of adults with epilepsy in tuberous sclerosis complex: A case series

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    Author
    McDermott, Danielle S
    Mirro, Emily A
    Fetrow, Kirsten
    Burdette, David E
    Chen, Stephanie
    Hopp, Jennifer
    Masel, Todd
    Johnson, Emily A
    Elefant, Felicia M K
    Le, Scheherazade
    Patra, Sanjay E
    Brown, Mesha-Gay
    Haneef, Zulfi
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    Date
    2021-02-27
    Journal
    Epilepsia Open
    Publisher
    Wiley-Blackwell
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1002/epi4.12481
    Abstract
    Objective: Tuberous sclerosis complex (TSC) is a genetic disorder primarily characterized by the development of multisystem benign tumors. Epilepsy is the most common neurologic manifestation, affecting 80%-90% of TSC patients. The diffuse structural brain abnormalities and the multifocal nature of epilepsy in TSC pose diagnostic challenges when evaluating patients for epilepsy surgery. Methods: We retrospectively reviewed the safety experience and efficacy outcomes of five adult TSC patients who were treated with direct brain-responsive neurostimulation (RNS System, NeuroPace, Inc). Results: The average follow-up duration was 20 months. All five patients were responders (≥50% disabling seizure reduction) at last follow-up. The median reduction in disabling seizures was 58% at 1 year and 88% at last follow-up. Three of the five patients experienced some period of seizure freedom ranging from 3 months to over 1 year. Significance: In this small case series, we report the first safety experience and efficacy outcomes in patients with TSC-associated drug-resistant focal epilepsy treated with direct brain-responsive neurostimulation.
    Rights/Terms
    © 2021 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.
    Keyword
    refractory epilepsy
    responsive neurostimulation
    tuberous sclerosis complex
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15886
    ae974a485f413a2113503eed53cd6c53
    10.1002/epi4.12481
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