• Login
    View Item 
    •   UMB Digital Archive
    • School of Dentistry
    • Theses and Dissertations School of Dentistry
    • View Item
    •   UMB Digital Archive
    • School of Dentistry
    • Theses and Dissertations School of Dentistry
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Interactions of immune and neuroendocrine systems in response to the superantigen staphylococcal enterotoxin B

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Find Full text
    Author
    Weng, Ching-Feng
    Advisor
    Franklin, Renty B.
    Tseng, Jeenan
    Date
    1994
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    The Immune and neuroendocrine systems interact with each other through cytokines and hormones. Staphylococcal enterotoxin B (SEB) is a powerful inducer of cytokines. The present studies were conducted to investigate the effect of SEB on the interaction between the immune and neuroendocrine systems. In monkeys challenged with SEB, efforts were made to investigate the interrelationships among the circulating cytokines, lymphoid cells, ACTH, and glucocorticoids (GCs). It was found that in dying monkeys there was an increase of cytokines (TNF, IL-2, IL-6, and IFN-gamma) that paralleled the appearance of ACTH and GCs and various lymphocyte subpopulations. To further study the complicated interactions among cytokines, lymphoid cells, and GCs, lymphoid cell cultures were established and stimulated with SEB, SEB plus dexamethasone (DEX), or SEB plus cytokines. DEX, if added after SEB to lymphoid cell cultures, generally suppressed SEB-induced mitosis. However, if DEX was added simultaneously with SEB, it enhanced SEB-induced mitosis of spleen cell cultures but not of lymphocytes from other lymphoid tissues. The enhancement appeared to be regulated primarily by IL-1 and to a lesser extent by IL-6. The significance of DEX-enhanced SEB-induced mitosis was further studied in mice challenged with SEB, or SEB plus DEX. Spleen cells from these mice were stimulated in culture with SEB, SEB plus DEX, and SEB plus cytokines. It was found that spleen cells from mice challenged with SEB or SEB plus DEX became tolerant to SEB-induced mitosis in culture. Because there were increases in the total number of splenic T cells and of Vbeta8 T cells, which are normally SEB-reactive, this tolerance appeared to be due to anergy rather than cell depletion. The anergic state of these cells could not be overcome by adding DEX and various cytokines to the lymphoid cell cultures. In conclusion, SEB may affects the interaction of the immune and neuroendocrine systems through the production of large amounts of cytokines that act on the neuroendocrine system which, in turn, releases ACTH and then GCs which subsequently regulate the immune system. The increased levels of cytokines and GCs may result in an over-stimulation of the nervous and immune systems resulting in pathophysiological changes of various organs and organ systems. A profound effect of GCs and SEB on the immune system is the development of anergy, which may confer resistance to subsequent SEB insult.
    Description
    University of Maryland, Baltimore. Neuroimmunology. Ph.D. 1994
    Keyword
    Biology, Neuroscience
    Biology, Animal Physiology
    Health Sciences, Immunology
    Enterotoxins--immunology
    Immune System
    Neurosecretory Systems
    Staphylococcus
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/1588
    Collections
    Theses and Dissertations School of Dentistry
    Theses and Dissertations All Schools

    entitlement

     
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.