JournalInternational Journal of Molecular Sciences
MetadataShow full item record
AbstractOrofacial pain is a universal predicament, afflicting millions of individuals worldwide. Research on the molecular mechanisms of orofacial pain has predominately focused on the role of neurons underlying nociception. However, aside from neural mechanisms, non-neuronal cells, such as Schwann cells and satellite ganglion cells in the peripheral nervous system, and microglia and astrocytes in the central nervous system, are important players in both peripheral and central processing of pain in the orofacial region. This review highlights recent molecular and cellular findings of the glia involvement and glia–neuron interactions in four common orofacial pain conditions such as headache, dental pulp injury, temporomandibular joint dysfunction/inflammation, and head and neck cancer. We will discuss the remaining questions and future directions on glial involvement in these four orofacial pain conditions. © 2021 by the authors.
SponsorsNational Institutes of Health
Dental pulp injury
Head and neck cancer
Satellite ganglia cells
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/15871