Show simple item record

dc.contributor.authorMcVaney, Kevin E
dc.contributor.authorPepe, Paul E
dc.contributor.authorMaloney, Lauren M
dc.contributor.authorBronsky, E Stein
dc.contributor.authorCrowe, Remle P
dc.contributor.authorAugustine, James J
dc.contributor.authorGilliam, Sheaffer O
dc.contributor.authorAsaeda, Glenn H
dc.contributor.authorEckstein, Marc
dc.contributor.authorMattu, Amal
dc.contributor.authorFumagalli, Roberto
dc.contributor.authorAufderheide, Tom P
dc.contributor.authorOsterholm, Michael T
dc.date.accessioned2021-05-28T17:47:49Z
dc.date.available2021-05-28T17:47:49Z
dc.date.issued2021-04-07
dc.identifier.urihttp://hdl.handle.net/10713/15847
dc.description.abstractBackground: Though variable, many major metropolitan cities reported profound and unprecedented increases in out-of-hospital cardiac arrest (OHCA) in early 2020. This study examined the relative magnitude of those increases and their relationship to COVID-19 prevalence. Methods: EMS (9-1-1 system) medical directors for 50 of the largest U.S. cities agreed to provide the aggregate, de-identified, pre-existing monthly tallies of OHCA among adults (age >18 years) occurring between January and June 2020 within their respective jurisdictions. Identical comparison data were also provided for corresponding time periods in 2018 and 2019. Equivalent data were obtained from the largest cities in Italy, United Kingdom and France, as well as Perth, Australia and Auckland, New Zealand. Findings: Significant OHCA escalations generally paralleled local prevalence of COVID-19. During April, most U.S. cities (34/50) had >20% increases in OHCA versus 2018–2019 which reflected high local COVID-19 prevalence. Thirteen observed 1·5-fold increases in OHCA and three COVID-19 epicenters had >100% increases (2·5-fold in New York City). Conversely, cities with lesser COVID-19 impact observed unchanged (or even diminished) OHCA numbers. Altogether (n = 50), on average, OHCA cases/city rose 59% during April (p = 0·03). By June, however, after mitigating COVID-19 spread, cities with the highest OHCA escalations returned to (or approached) pre-COVID OHCA numbers while cities minimally affected by COVID-19 during April (and not experiencing OHCA increases), then had marked OHCA escalations when COVID-19 began to surge locally. European, Australian, and New Zealand cities mirrored the U.S. experience. Interpretation: Most metropolitan cities experienced profound escalations of OHCA generally paralleling local prevalence of COVID-19. Most of these patients were pronounced dead without COVID-19 testing.en_US
dc.description.urihttps://doi.org/10.1016/j.eclinm.2021.100815en_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofEClinicalMedicineen_US
dc.rights© 2021 The Authors.en_US
dc.subjectOHCAen_US
dc.subject.meshCOVID-19en_US
dc.subject.meshOut-of-Hospital Cardiac Arresten_US
dc.subject.meshPrevalenceen_US
dc.subject.meshUrban Populationen_US
dc.titleThe relationship of large city out-of-hospital cardiac arrests and the prevalence of COVID-19en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.eclinm.2021.100815
dc.identifier.pmid33997730
dc.source.volume34
dc.source.beginpage100815
dc.source.endpage
dc.source.countryEngland


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record