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    Exploiting unique features of the gut-brain interface to combat gastrointestinal cancer

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    Author
    Schledwitz, Alyssa
    Xie, Guofeng
    Raufman, Jean-Pierre
    Date
    2021-05-17
    Journal
    Journal of Clinical Investigation
    Publisher
    American Society for Clinical Investigation
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1172/JCI143776
    Abstract
    The gastrointestinal tract comprises a complex ecosystem with extensive opportunities for functional interactions between neoplastic epithelial cells and stromal, immune, neuronal, glial, and other cell types, as well as microorganisms and metabolites within the gut lumen. In this Review, we focus on interactions between gastrointestinal cancers and elements of the central and enteric nervous systems. This previously understudied but rapidly emerging area of investigation has blossomed in recent years, particularly with respect to improved understanding of neural contributions to the development and progression of esophageal, gastric, pancreatic, and colon neoplasia. Cancer neuroscience offers great promise to advance our understanding of how neural-cancer interactions promote alimentary tract neoplasia. The resulting mechanistic insights can be leveraged to identify diagnostic and prognostic biomarkers, and to develop novel therapeutic interventions.
    Keyword
    gastrointestinal cancer
    Central Nervous System
    Enteric Nervous System
    Gastrointestinal Neoplasms
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15846
    ae974a485f413a2113503eed53cd6c53
    10.1172/JCI143776
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