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dc.contributor.authorUhlig, Johannes
dc.contributor.authorLukovic, Jelena
dc.contributor.authorDawson, Laura A
dc.contributor.authorPatel, Reema A
dc.contributor.authorCavnar, Michael J
dc.contributor.authorKim, Hyun S
dc.date.accessioned2021-05-28T16:44:16Z
dc.date.available2021-05-28T16:44:16Z
dc.date.issued2021-05-18
dc.identifier.urihttp://hdl.handle.net/10713/15842
dc.description.abstractColorectal cancer was the third most common malignancy worldwide in 2018, and most patients present with or develop distant metastases. Colorectal liver metastases are most commonly observed because of the vascular drainage of the colon and superior rectum. Current guidelines recommend surgical resection as first-line treatment; however, 80% to 90% of patients with colorectal liver metastases are ineligible for primary resection. For patients with unresectable disease, a multidisciplinary treatment approach is favored, incorporating systemic therapy and a toolbox of local ablative therapies. These treatments either aim at cytoreduction to enable a conversion to surgical resectability or control of disease progression and spread. Each of these treatments carries unique outcomes and risk profiles, thereby contributing to an individualized treatment strategy for patients with colorectal liver metastases. This review summarizes evidence on hepatic artery infusion, stereotactic body radiation therapy, thermal ablation, transarterial chemoembolization with drug-eluding beads, and transarterial radioembolization for treatment of colorectal liver metastases. Results of large-scale prospective and retrospective studies and international guidelines are discussed to provide detailed background on the current and prospective use of local ablative techniques in management of colorectal liver metastases.en_US
dc.description.urihttps://doi.org/10.1200/EDBK_320519en_US
dc.language.isoenen_US
dc.publisherAmerican Society of Clinical Oncologyen_US
dc.relation.ispartofAmerican Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meetingen_US
dc.subjectcolorectal canceren_US
dc.subject.lcshColon (Anatomy)--Canceren_US
dc.subject.lcshRectum--Canceren_US
dc.subject.lcshMetastasisen_US
dc.subject.meshColorectal Neoplasms--therapyen_US
dc.titleLocoregional Therapies for Colorectal Cancer Liver Metastases: Options Beyond Resectionen_US
dc.typeArticleen_US
dc.identifier.doi10.1200/EDBK_320519
dc.identifier.pmid34010047
dc.source.volume41
dc.source.beginpage133
dc.source.endpage146
dc.source.countryUnited States


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