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dc.contributor.authorTebben, Kieran
dc.contributor.authorBradwell, Katie
dc.contributor.authorSerre, David
dc.date.accessioned2021-05-27T19:31:00Z
dc.date.available2021-05-27T19:31:00Z
dc.date.issued2021-05-08
dc.identifier.urihttp://hdl.handle.net/10713/15821
dc.description.abstractPlasmodium parasites, the cause of malaria, have a complex life cycle, infecting alternatively vertebrate hosts and female Anopheles mosquitoes and undergoing intra- and extra-cellular development in several organs of these hosts. Most of the ~5000 protein-coding genes present in Plasmodium genomes are only expressed at specific life stages, and different genes might therefore be subject to different selective pressures depending on the biological activity of the parasite and its microenvironment at this point in development. Here, we estimate the selective constraints on the protein-coding sequences of all annotated genes of rodent and primate Plasmodium parasites and, using data from scRNA-seq experiments spanning many developmental stages, analyze their variation with regard to when these genes are expressed in the parasite life cycle. Our study reveals extensive variation in selective constraints throughout the parasites' development and highlights stages that are evolving more rapidly than others. These findings provide novel insights into the biology of these parasites and could provide important information to develop better treatment strategies or vaccines against these medically-important organisms. © 2021 The Authorsen_US
dc.description.urihttps://doi.org/10.1016/j.meegid.2021.104908en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofInfection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseasesen_US
dc.rightsCopyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.en_US
dc.subjectPlasmodiumen_US
dc.subjectSelectionen_US
dc.subjectscRNA-seqen_US
dc.titleVariation in selective constraints along the Plasmodium life cycleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.meegid.2021.104908
dc.identifier.pmid33975022
dc.source.volume92
dc.source.beginpage104908
dc.source.endpage
dc.source.countryUnited States
dc.source.countryNetherlands


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