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dc.contributor.authorHuang, Xiaoyu
dc.contributor.authorGe, Yang
dc.contributor.authorYang, Bina
dc.contributor.authorHan, Qi
dc.contributor.authorZhou, Wen
dc.contributor.authorLiang, Jingou
dc.contributor.authorLi, Mingyun
dc.contributor.authorPeng, Xian
dc.contributor.authorRen, Biao
dc.contributor.authorYang, Bangcheng
dc.contributor.authorWeir, Michael D.
dc.contributor.authorGuo, Qiang
dc.contributor.authorWang, Haohao
dc.contributor.authorZhou, Xinxuan
dc.contributor.authorLu, Xugang
dc.contributor.authorOates, Thomas W.
dc.contributor.authorXu, Hockin H.K.
dc.contributor.authorDeng, Dongmei
dc.contributor.authorZhou, Xuedong
dc.contributor.authorCheng, Lei
dc.date.accessioned2021-05-27T19:25:35Z
dc.date.available2021-05-27T19:25:35Z
dc.date.issued2021-05-15
dc.identifier.urihttp://hdl.handle.net/10713/15820
dc.description.abstractPeri-implantitis are a major problem causing implant failure these days. Accordingly, anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue. Micro-arc oxidation (MAO) treatment is a way to form an oxidation film on the surface of metallic materials. The method shows good osteogenic properties but weak antibacterial effect. Therefore, we developed combined strategies to combat severe peri-implantitis, which included the use of a novel compound, PD, comprising dendrimers poly(amidoamine) (PAMAM) loading dimethylaminododecyl methacrylate (DMADDM) as well as MAO treatment. Here, we explored the chemical properties of the novel compound PD, and proved that this compound was successfully synthesized, with the loading efficiency and encapsulation efficiency of 23.91% and 31.42%, respectively. We further report the two-stage double benefits capability of PD + MAO: (1) in the first stage, PD + MAO could decrease the adherence and development of biofilms by releasing DMADDM in the highly infected first stage after implant surgery both in vitro and in vivo; (2) in the second stage, PD + MAO indicated mighty anti-infection and osteoconductive characteristics in a rat model of peri-implantitis in vivo. This study first reports the two-staged, double benefits of PD + MAO, and demonstrates its potential in clinical applications for inhibiting peri-implantitis, especially in patients with severe infection risk. © 2021 The Authorsen_US
dc.description.sponsorshipNational Key Research and Development Program of Chinaen_US
dc.description.urihttps://doi.org/10.1016/j.bioactmat.2021.04.041en_US
dc.language.isoenen_US
dc.publisherKeAi Communications Co.en_US
dc.relation.ispartofBioactive Materialsen_US
dc.subjectAnimal modelen_US
dc.subjectBioactive and therapeuticen_US
dc.subjectDimethylaminododecyl methacrylateen_US
dc.subjectOsseointegrationen_US
dc.subjectPeri-implantitisen_US
dc.titleNovel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivo and in vitroen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bioactmat.2021.04.041
dc.source.volume6
dc.source.issue12
dc.source.beginpage4568
dc.source.endpage4579


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