Show simple item record

dc.contributor.authorSkov-Jeppesen, Kirsa
dc.contributor.authorHepp, Nicola
dc.contributor.authorOeke, Jannika
dc.contributor.authorHansen, Morten Steen
dc.contributor.authorJafari, Abbas
dc.contributor.authorSvane, Maria Saur
dc.contributor.authorBalenga, Nariman
dc.contributor.authorOlson, John A
dc.contributor.authorFrost, Morten
dc.contributor.authorKassem, Moustapha
dc.contributor.authorMadsbad, Sten
dc.contributor.authorBeck Jensen, Jens-Erik
dc.contributor.authorHolst, Jens Juul
dc.contributor.authorRosenkilde, Mette Marie
dc.contributor.authorHartmann, Bolette
dc.date.accessioned2021-05-20T15:04:25Z
dc.date.available2021-05-20T15:04:25Z
dc.date.issued2021-04-14
dc.identifier.urihttp://hdl.handle.net/10713/15720
dc.description.abstractGlucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-2 (GLP-2) are gut hormones secreted postprandially. In healthy humans, both hormones decrease bone resorption accompanied by a rapid reduction in parathyroid hormone (PTH). The aim of this study was to investigate whether the changes in bone turnover after meal intake and after GIP- and GLP-2 injections, respectively, are mediated via a reduction in PTH secretion. This was tested in female patients with hypoparathyroidism given a standardized liquid mixed-meal test (n = 7) followed by a peptide injection test (n = 4) using a randomized crossover design. We observed that the meal- and GIP- but not the GLP-2-induced changes in bone turnover markers were preserved in the patients with hypoparathyroidism. To understand the underlying mechanisms, we examined the expression of the GIP receptor (GIPR) and the GLP-2 receptor (GLP-2R) in human osteoblasts and osteoclasts as well as in parathyroid tissue. The GIPR was expressed in both human osteoclasts and osteoblasts, whereas the GLP-2R was absent or only weakly expressed in osteoclasts. Furthermore, both GIPR and GLP-2R were expressed in parathyroid tissue. Our findings suggest that the GIP-induced effect on bone turnover may be mediated directly via GIPR expressed in osteoblasts and osteoclasts and that this may occur independent of PTH. In contrast, the effect of GLP-2 on bone turnover seems to depend on changes in PTH and may be mediated through GLP-2R in the parathyroid gland. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR). © 2021 The Authors.en_US
dc.description.urihttps://doi.org/10.1002/jbmr.4308en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of Bone and Mineral Researchen_US
dc.rights© 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).en_US
dc.subjectGIPen_US
dc.subjectGLP-2en_US
dc.subjectBiochemical markers of bone turnoveren_US
dc.subjectBone turnoveren_US
dc.subject.meshBone Remodelingen_US
dc.subject.meshOsteoblastsen_US
dc.subject.meshOsteoclastsen_US
dc.titleThe Antiresorptive Effect of GIP, but not GLP-2, Is Preserved in Patients With Hypoparathyroidism-A Randomized Crossover Studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/jbmr.4308
dc.identifier.pmid33852173
dc.source.countryUnited States


This item appears in the following Collection(s)

Show simple item record