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    Synergistic Effect of Bazedoxifene and PARP Inhibitor in the Treatment of Ovarian Cancer Regardless of BRCA Mutation.

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    Author
    Zhang, Ruijie
    Wang, Tiffany
    Lin, Jiayuh
    Date
    2021-05
    Journal
    Anticancer Research
    Publisher
    International Institute of Anticancer Research
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.21873/anticanres.15003
    Abstract
    BACKGROUND/AIM: Poly (ADP-ribose) polymerase inhibitors (PARPis) are one of the targeted therapies proven to treat breast cancer gene (BRCA)-mutant ovarian cancer. Because most ovarian cancers are BRCA wild-type, it is necessary to extend the usage of PARPis. In the present study, we combined the PARPi, talazoparib, and the IL-6 inhibitor, bazedoxifene, for the treatment of human ovarian cancer cells. MATERIALS AND METHODS: The human ovarian cancer cell lines, SKOV3, UWB1.289 (BRCA1-null) and OV75, were treated with talazoparib and bazedoxifene, as monotherapy or combination treatment. The effects of treatment on cell viability, migration, growth and colony formation were examined. Western blot was used to investigate pathways that may be involved in the antitumor effects of the two agents. RESULTS: The combination of talazoparib and bazedoxifene showed synergistic inhibition of cell viability, cell migration, cell growth, and cell colony formation on all the studied cell lines. The expression of p-AKT, c-myc, p-ERK, ERα was inhibited, and γ-H2AX expression was induced. CONCLUSION: Combined inhibition of PARP and IL-6 may be an efficacious treatment for ovarian cancer, independently of BRCA mutation status.
    Rights/Terms
    Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
    Keyword
    BRCA
    IL-6 inhibitor
    PARP
    bazedoxifene
    ovarian cancer
    talazoparib
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15695
    ae974a485f413a2113503eed53cd6c53
    10.21873/anticanres.15003
    Scopus Count
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