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dc.contributor.authorBurgio, Stefano
dc.contributor.authorConway de Macario, Everly
dc.contributor.authorMacario, Alberto Jl
dc.contributor.authorCappello, Francesco
dc.date.accessioned2021-05-18T17:02:24Z
dc.date.available2021-05-18T17:02:24Z
dc.date.issued2021-05-11
dc.identifier.urihttp://hdl.handle.net/10713/15671
dc.description.abstractA few reports suggest that molecular mimicry can have a role in determining the more severe and deadly forms of COVID-19, inducing endothelial damage, disseminated intravascular coagulation, and multiorgan failure. Heat shock proteins/molecular chaperones can be involved in these molecular mimicry phenomena. However, tumor cells can display on their surface heat shock proteins/molecular chaperones that are mimicked by SARS-CoV-2 molecules (including the Spike protein), similarly to what happens in other bacterial or viral infections. Since molecular mimicry between SARS-CoV-2 and tumoral proteins can elicit an immune reaction in which antibodies or cytotoxic cells produced against the virus cross-react with the tumor cells, we want to prompt clinical studies to evaluate the impact of SARS-CoV-2 infection on prognosis and follow up of various forms of tumors. These topics, including a brief historical overview, are discussed in this paper.en_US
dc.description.urihttps://doi.org/10.1007/s12192-021-01211-7en_US
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc8112475/en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofCell Stress & Chaperonesen_US
dc.subjectCOVID-19en_US
dc.subjectCanceren_US
dc.subjectImmunological cross-reactionen_US
dc.subjectMolecular mimicryen_US
dc.subjectSARS-CoV-2en_US
dc.subjectShared epitopesen_US
dc.titleSARS-CoV-2 in patients with cancer: possible role of mimicry of human molecules by viral proteins and the resulting anti-cancer immunityen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s12192-021-01211-7
dc.identifier.pmid33977496
dc.source.countryNetherlands


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