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dc.contributor.authorJellestad, Lena
dc.contributor.authorZeffiro, Thomas
dc.contributor.authorPiccirelli, Marco
dc.contributor.authorMalamud, Jolanda
dc.contributor.authorKlimke, Benedikt B M
dc.contributor.authorRauen, Katrin
dc.contributor.authorRufer, Michael
dc.contributor.authorOrr, Scott P
dc.contributor.authorMueller-Pfeiffer, Christoph
dc.date.accessioned2021-05-17T14:57:55Z
dc.date.available2021-05-17T14:57:55Z
dc.date.issued2021-04-24
dc.identifier.urihttp://hdl.handle.net/10713/15663
dc.description.abstractObjective: Pharmacologic and behavioral interventions that block reconsolidation of reactivated fear memory have demonstrated only limited success in modifying stronger and long-standing fear memories. Given the efficacy of Eye Movement Desensitization and Reprocessing (EMDR) in treating PTSD, pursuit eye movements are a promising and novel intervention for studies of human memory reconsolidation. Here, we examined the efficacy of pursuit eye movements in interfering with reconsolidation of conditioned fear memories. Methods: We conducted a 3-day differential Pavlovian fear conditioning procedure in healthy adults, using videos of biologically prepared stimuli (tarantulas), partly reinforced with electrical shocks while recording skin conductance response (SCR) as a measure of autonomic conditioned responses. Fear conditioning was performed on Day 1. On Day 2, 38 participants were randomized into groups performing pursuit eye movements either immediately after fear memory reactivation, when the fear memory was stable, or 10 min later, when the fear memory was assumed to be more labile. On Day 3, fear memory strength was assessed by SCR to both reactivated and nonreactivated fear memories. Results: Strong differential conditioning to the spider stimuli were observed during both fear acquisition and fear memory reactivation. Reactivated fear memory conditioned responses of participants performing pursuit eye movements after a 10-min delay were significantly smaller in the reinstatement phase (0.16 μS; 95% CI [0.02, 0.31]). Conclusions: Pursuit eye movements were effective in reducing fear-conditioned SCR in reinstatement. This result supports the theoretical proposition that EMDR can interfere with reactivated fear memory reconsolidation. © 2021 The Authorsen_US
dc.description.urihttps://doi.org/10.1016/j.ijpsycho.2021.04.006en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofInternational Journal of Psychophysiologyen_US
dc.rightsCopyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.en_US
dc.subjectFear conditioningen_US
dc.subjectMemory consolidationen_US
dc.subjectMemory reconsolidationen_US
dc.subjectPosttraumatic stress disorder (PTSD)en_US
dc.subjectSkin conductanceen_US
dc.titleInterfering with fear memories by eye movement desensitization and reprocessingen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ijpsycho.2021.04.006
dc.identifier.pmid33901511
dc.source.volume166
dc.source.beginpage9
dc.source.endpage18
dc.source.countryNetherlands


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