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dc.contributor.authorFrei, Jeannine A
dc.contributor.authorBrandenburg, Cheryl
dc.contributor.authorNestor, Jonathan E
dc.contributor.authorHodzic, Didier M
dc.contributor.authorPlachez, Celine
dc.contributor.authorMcNeill, Helen
dc.contributor.authorDykxhoorn, Derek M
dc.contributor.authorNestor, Michael W
dc.contributor.authorBlatt, Gene J
dc.contributor.authorLin, Yu-Chih
dc.date.accessioned2021-05-17T14:23:48Z
dc.date.available2021-05-17T14:23:48Z
dc.date.issued2021-05-13
dc.identifier.urihttp://hdl.handle.net/10713/15659
dc.description.abstractGenetic studies have linked FAT1 (FAT atypical cadherin 1) with autism spectrum disorder (ASD), however, the role that FAT1 plays in ASD remains unknown. In mice, the function of Fat1 has been primarily implicated in embryonic nervous system development with less known about its role in postnatal development. We show for the first time that FAT1 protein is expressed in mouse postnatal brains and is enriched in the cerebellum, where it localizes to granule neurons and Golgi cells in the granule layer, as well as inhibitory neurons in the molecular layer. Furthermore, subcellular characterization revealed FAT1 localization in neurites and soma of granule neurons, as well as being present in the synaptic plasma membrane and postsynaptic densities. Interestingly, FAT1 expression was decreased in induced pluripotent stem cell (iPSC)-derived neural precursor cells (NPCs) from individuals with ASD. These findings suggest a novel role for FAT1 in postnatal development and may be particularly important for cerebellum function. As the cerebellum is one of the vulnerable brain regions in ASD, our study warrants further investigation of FAT1 in the disease etiology.en_US
dc.description.urihttps://doi.org/10.1242/bio.056457en_US
dc.language.isoenen_US
dc.publisherThe Company of Biologists Ltd.en_US
dc.relation.ispartofBiology Openen_US
dc.rights© 2021. Published by The Company of Biologists Ltd.en_US
dc.subjectAutismen_US
dc.subjectCadherinen_US
dc.subjectCerebellumen_US
dc.subjectFAT1en_US
dc.subjectGranule cellsen_US
dc.subjectNeural precursor cellsen_US
dc.titlePostnatal expression profiles of atypical cadherin FAT1 suggest its role in autismen_US
dc.typeArticleen_US
dc.identifier.doi10.1242/bio.056457
dc.identifier.pmid33983383
dc.source.countryEngland


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