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dc.contributor.authorOrr, Cody
dc.contributor.authorMasur, Henry
dc.contributor.authorKottilil, Shyam
dc.contributor.authorMeissner, Eric G
dc.date.accessioned2021-05-11T20:28:12Z
dc.date.available2021-05-11T20:28:12Z
dc.date.issued2021-03-13
dc.identifier.issn2328-8957
dc.identifier.urihttp://hdl.handle.net/10713/15621
dc.description.abstractTo identify immunologic correlates of hepatitis C virus (HCV) relapse after direct-acting antiviral (DAA) therapy, we quantified select immune transcripts in whole blood from noncirrhotic HCV subjects treated with 4-6 weeks of DAAs. We identified specific markers of natural killer-cell and CD8+ T-cell function (GZMB, PRF1, NKp46) with higher expression in subjects who relapsed. These findings suggest a role for host immunity in HCV eradication with ultrashort DAA therapy. We quantified whole blood immune transcripts in noncirrhotic HCV subjects treated with shortcourse antiviral therapy. Markers of natural killer-cell and CD8+ T-cell function had higher expression in virologic relapsers, suggesting a role for host immunity in HCV eradication.en_US
dc.description.urihttps://doi.org/10.1093/ofid/ofab118en_US
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc8082583/en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofOpen Forum Infectious Diseasesen_US
dc.rights© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.en_US
dc.subjectdirect acting antiviralen_US
dc.subjectgene expression analysisen_US
dc.subjecthepatitis C virusen_US
dc.subjectrelapseen_US
dc.subjectsustained virologic responseen_US
dc.titleHepatitis C Virus Relapse After Ultrashort Direct-Acting Antiviral Therapy Associates With Expression of Genes Involved With Natural Killer-Cell and CD8 T-Cell Function.en_US
dc.typeArticleen_US
dc.identifier.doi10.1093/ofid/ofab118
dc.identifier.pmid33959672
dc.source.volume8
dc.source.issue4
dc.source.beginpageofab118
dc.source.endpage
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.identifier.journalOpen forum infectious diseases


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