The importance of genomic analysis in cracking the coronavirus pandemic
JournalExpert Review of Molecular Diagnostics
PublisherTaylor and Francis Inc.
MetadataShow full item record
AbstractIntroduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has pushed the scientific community to undertake intense research efforts. Understanding SARS-CoV-2 biology is necessary to discover therapeutic or preventive strategies capable of containing the pandemic. Knowledge of the structural characteristics of the virus genome and proteins is essential to find targets for therapies and immunological interventions.Areas covered: This review covers different areas of expertise, genomic analysis of circulating strains, structural biology, viral mutations, molecular diagnostics, disease, and vaccines. In particular, the review is focused on the molecular approaches and modern clinical strategies used in these fields.Expert opinion: Molecular approaches to SARS-CoV-2 pandemic have been critical to shorten time for new diagnostic, therapeutic and prevention strategies. In this perspective, the entire scientific community is moving in the same direction. Vaccines, together with the development of new drugs to treat the disease, represent the most important strategy to protect human from viral disease and prevent further spread. In this regard, new molecular technologies have been successfully implemented. The use of a novel strategy of communication is suggested for a better diffusion to the broader public of new data and results.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/15601
- Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses.
- Authors: Artese A, Svicher V, Costa G, Salpini R, Di Maio VC, Alkhatib M, Ambrosio FA, Santoro MM, Assaraf YG, Alcaro S, Ceccherini-Silberstein F
- Issue date: 2020 Dec
- The British variant of the new coronavirus-19 (Sars-Cov-2) should not create a vaccine problem.
- Authors: Conti P, Caraffa A, Gallenga CE, Kritas SK, Frydas I, Younes A, Di Emidio P, Tetè G, Pregliasco F, Ronconi G
- Issue date: 2021 Jan-Feb
- The 2020 race towards SARS-CoV-2 specific vaccines.
- Authors: Karpiński TM, Ożarowski M, Seremak-Mrozikiewicz A, Wolski H, Wlodkowic D
- Issue date: 2021
- Proteomic Approaches to Study SARS-CoV-2 Biology and COVID-19 Pathology.
- Authors: Haas P, Muralidharan M, Krogan NJ, Kaake RM, Hüttenhain R
- Issue date: 2021 Feb 5
- The diagnostic methods in the COVID-19 pandemic, today and in the future.
- Authors: Wu SY, Yau HS, Yu MY, Tsang HF, Chan LWC, Cho WCS, Shing Yu AC, Yuen Yim AK, Li MJW, Wong YKE, Pei XM, Cesar Wong SC
- Issue date: 2020 Sep