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dc.contributor.authorSapijanskaitė-Banevič, Birutė
dc.contributor.authorPalskys, Vykintas
dc.contributor.authorVaickelionienė, Rita
dc.contributor.authorŠiugždaitė, Jūratė
dc.contributor.authorKavaliauskas, Povilas
dc.contributor.authorGrybaitė, Birutė
dc.contributor.authorMickevičius, Vytautas
dc.date.accessioned2021-05-07T14:26:32Z
dc.date.available2021-05-07T14:26:32Z
dc.date.issued2021-04-29
dc.identifier.urihttp://hdl.handle.net/10713/15596
dc.description.abstractThe p-aminobenzoic acid was applied for the synthesis of substituted 1-phenyl-5-oxopyrrolidine derivatives containing benzimidazole, azole, oxadiazole, triazole, dihydrazone, and dithiosemicarbazide moieties in the structure. All the obtained compounds were evaluated for their in vitro antimicrobial activity against Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Salmonella enteritidis, Escherichia coli, and Pseudomonas aeruginosa by using MIC and MBC assays. This study showed a good bactericidal activity of γ-amino acid and benzimidazoles derivatives. The antimicrobial activity of the most promising compounds was higher than ampicillin. Furthermore, two benzimidazoles demonstrated good antimicrobial activity against L. monocytogenes (MIC 15.62 µg/mL) that was four times more potent than ampicillin (MIC 65 µg/mL). Further studies are needed to better understand the mechanism of the antimicrobial activity as well as to generate antimicrobial compounds based on the 1-phenyl-5-oxopyrrolidine scaffold.en_US
dc.description.urihttps://doi.org/10.3390/molecules26092597en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofMolecules (Basel, Switzerland)en_US
dc.subject2-pyrrolidinoneen_US
dc.subjectantimicrobial activityen_US
dc.subjectazolesen_US
dc.subjectbenzimidazoleen_US
dc.subjecthydrazidesen_US
dc.titleSynthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on -Aminobenzoic Aciden_US
dc.typeArticleen_US
dc.identifier.doi10.3390/molecules26092597
dc.identifier.pmid33946936
dc.source.volume26
dc.source.issue9
dc.source.countrySwitzerland


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