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dc.contributor.authorPaladino, Letizia
dc.contributor.authorVitale, Alessandra Maria
dc.contributor.authorSantonocito, Radha
dc.contributor.authorPitruzzella, Alessandro
dc.contributor.authorCipolla, Calogero
dc.contributor.authorGraceffa, Giuseppa
dc.contributor.authorBucchieri, Fabio
dc.contributor.authorConway de Macario, Everly
dc.contributor.authorMacario, Alberto J L
dc.contributor.authorRappa, Francesca
dc.date.accessioned2021-05-07T12:52:55Z
dc.date.available2021-05-07T12:52:55Z
dc.date.issued2021-04-18
dc.identifier.urihttp://hdl.handle.net/10713/15593
dc.description.abstractThyroid cancers are the most common of the endocrine system malignancies and progress must be made in the areas of differential diagnosis and treatment to improve patient management. Advances in the understanding of carcinogenic mechanisms have occurred in various fronts, including studies of the chaperone system (CS). Components of the CS are found to be quantitatively increased or decreased, and some correlations have been established between the quantitative changes and tumor type, prognosis, and response to treatment. These correlations provide the basis for identifying distinctive patterns useful in differential diagnosis and for planning experiments aiming at elucidating the role of the CS in tumorigenesis. Here, we discuss studies of the CS components in various thyroid cancers (TC). The chaperones belonging to the families of the small heat-shock proteins Hsp70 and Hsp90 and the chaperonin of Group I, Hsp60, have been quantified mostly by immunohistochemistry and Western blot in tumor and normal control tissues and in extracellular vesicles. Distinctive differences were revealed between the various thyroid tumor types. The most frequent finding was an increase in the chaperones, which can be attributed to the augmented need for chaperones the tumor cells have because of their accelerated metabolism, growth, and division rate. Thus, chaperones help the tumor cell rather than protect the patient, exemplifying chaperonopathies by mistake or collaborationism. This highlights the need for research on chaperonotherapy, namely the development of means to eliminate/inhibit pathogenic chaperones.en_US
dc.description.urihttps://doi.org/10.3390/ijms22084196en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.subjectHsp27en_US
dc.subjectHsp60en_US
dc.subjectHsp70en_US
dc.subjectHsp90en_US
dc.subjectchaperone systemen_US
dc.subjectchaperonopathies by mistakeen_US
dc.subjectchaperonotherapyen_US
dc.subjectdifferential diagnosisen_US
dc.subjectmolecular chaperonesen_US
dc.subjectthyroid tumorsen_US
dc.titleMolecular Chaperones and Thyroid Canceren_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms22084196
dc.identifier.pmid33919591
dc.source.volume22
dc.source.issue8
dc.source.countrySwitzerland


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