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    Polycystic Ovary Syndrome, Affective Symptoms, and Neuroactive Steroids: a Focus on Allopregnanolone

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    Author
    Standeven, Lindsay R
    Olson, Elizabeth
    Leistikow, Nicole
    Payne, Jennifer L
    Osborne, Lauren M
    Hantsoo, Liisa
    Date
    2021-04-21
    Journal
    Current Psychiatry Reports
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1007/s11920-021-01244-w
    Abstract
    Purpose of Review: To provide an overview of existing studies on alterations in gonadal and neuroactive steroids (NASs) and mood symptoms among women with polycystic ovary syndrome (PCOS). Recent Findings: Recent studies have demonstrated a previously underappreciated association between PCOS and comorbid depression and anxiety. However, most studies on affective symptoms among women with PCOS have been cross-sectional, limiting our knowledge about fluctuations in symptoms over the menstrual cycle and reproductive lifespan for women with PCOS, as well as the potential interplay between NAS alterations and mood symptoms. Changes in the NAS allopregnanolone (ALLO) have been implicated in several reproductive-related psychiatric disorders (e.g., premenstrual dysphoric disorder (PMDD) and postpartum depression (PPD)) as well as in normal reproductive functioning, warranting further investigation for its potential role in the psychiatric symptoms observed in women with PCOS. Summary: Prospective studies evaluating associations between psychiatric symptoms and NAS are needed to elucidate the biological causes of the increased rates of psychiatric symptoms among women with PCOS and inform clinical treatment. ALLO, with its role in normal reproductive function, menstrual dysregulation among women with PCOS, and reproductive-related psychiatric conditions, makes it a particularly intriguing candidate for future investigation. © 2021, The Author(s).
    Keyword
    Anxiety
    Depression
    Mood
    Neurosteroids
    Polycystic ovary syndrome
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15556
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11920-021-01244-w
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