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dc.contributor.authorCao, Dong-Yuan
dc.contributor.authorHu, Bo
dc.contributor.authorXue, Yang
dc.contributor.authorHanson, Shelby
dc.contributor.authorDessem, Dean
dc.contributor.authorDorsey, Susan G
dc.contributor.authorTraub, Richard J
dc.date.accessioned2021-05-03T12:21:56Z
dc.date.available2021-05-03T12:21:56Z
dc.date.issued2021-04-20
dc.identifier.urihttp://hdl.handle.net/10713/15546
dc.description.abstractChronic Overlapping Pain Conditions, including irritable bowel syndrome (IBS) and temporomandibular disorder (TMD), represent a group of idiopathic pain conditions that likely have peripheral and central mechanisms contributing to their pathology, but are poorly understood. These conditions are exacerbated by stress and have a female predominance. The presence of one condition predicts the presence or development of additional conditions, making this a significant pain management problem. The current study was designed to determine if the duration and magnitude of peripheral sensitization and spinal central sensitization differs between restraint stress-induced visceral hypersensitivity (SIH) and chronic comorbid pain hypersensitivity (CPH; stress during pre-existing orofacial pain). SIH in female rats, as determined by the visceromotor response, persisted at least four but resolved by seven weeks. In contrast, CPH persisted at least seven weeks. Surprisingly, colonic afferents in both SIH and CPH rats were sensitized at seven weeks. CPH rats also had referred pain through seven weeks, but locally anesthetizing the colon only attenuated the referred pain through four weeks, suggesting a transition to colonic afferent independent central sensitization. Different phenotypes of dorsal horn neurons were sensitized in the CPH rats seven weeks post stress compared to four weeks or SIH rats. The current study suggests differential processing of colonic afferent input to the lumbosacral spinal cord contributes to visceral hypersensitivity during comorbid chronic pain conditions. Perspective: Chronic Overlapping Pain Conditions represent a unique challenge in pain management. The diverse nature of peripheral organs hinders a clear understanding of underlying mechanisms accounting for the comorbidity. This study highlights a mismatch between the condition-dependent behavior and peripheral and spinal mechanisms that contribute to visceral pain hypersensitivity.en_US
dc.description.urihttps://doi.org/10.1016/j.jpain.2021.04.004en_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofJournal of Painen_US
dc.rightsCopyright © 2021. Published by Elsevier Inc.en_US
dc.subjectcomorbid hypersensitivityen_US
dc.subjectdorsal horn neuronsen_US
dc.subjectfemale ratsen_US
dc.subjectprimary afferentsen_US
dc.subjectreferred painen_US
dc.subjectstressen_US
dc.subjectvisceral painen_US
dc.titleDifferential activation of colonic afferents and dorsal horn neurons underlie stress-induced and comorbid visceral hypersensitivity in female ratsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jpain.2021.04.004
dc.identifier.pmid33887444
dc.source.countryUnited States


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