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dc.contributor.authorTu, Yuan-Po
dc.contributor.authorIqbal, Jameel
dc.contributor.authorO'Leary, Timothy
dc.date.accessioned2021-04-29T17:22:42Z
dc.date.available2021-04-29T17:22:42Z
dc.date.issued2021-04-20
dc.identifier.urihttp://hdl.handle.net/10713/15539
dc.description.abstractDiagnosis of SARS-CoV-2 (COVID-19) requires confirmation by reverse transcription-polymerase chain reaction (RT-PCR). Abbott ID NOW provides fast results but has been criticized for low sensitivity. Here we determine the sensitivity of ID NOW in an ambulatory population presented for testing. The study enrolled 785 symptomatic patients, of whom 21 were positive by both ID NOW and RT-PCR, and 2 only by RT-PCR. All 189 asymptomatic patients tested negative. The positive percent agreement between the ID NOW assay and the RT-PCR assay was 91.3%, and negative percent agreement was 100%. The results from the current study were included into a larger systematic review of literature where at least 20 subjects were simultaneously tested using ID NOW and RT-PCR. The overall sensitivity for ID NOW assay was calculated at 84% (95% confidence interval 55-96%) and had the highest correlation to RT-PCR at viral loads most likely to be associated with transmissible infections.en_US
dc.description.urihttps://doi.org/10.7554/eLife.65726en_US
dc.language.isoenen_US
dc.publishereLife Sciences Publicationsen_US
dc.relation.ispartofeLifeen_US
dc.subjectCOVID-19en_US
dc.subjectID NOWen_US
dc.subjectRT-PCRen_US
dc.subjectSARS-CoV-2en_US
dc.subjectambulatoryen_US
dc.subjecthumanen_US
dc.subjectmedicineen_US
dc.subjectsensitivityen_US
dc.titleSensitivity of ID NOW and RT-PCR for detection of SARS-CoV-2 in an ambulatory populationen_US
dc.typeArticleen_US
dc.identifier.doi10.7554/eLife.65726
dc.identifier.pmid33876726
dc.source.volume10
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryEngland


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