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dc.contributor.authorHe, Junyun
dc.contributor.authorRitzel, Rodney M
dc.contributor.authorWu, Junfang
dc.date.accessioned2021-04-28T15:06:45Z
dc.date.available2021-04-28T15:06:45Z
dc.date.issued2021-04-09
dc.identifier.urihttp://hdl.handle.net/10713/15532
dc.description.abstractThe voltage-gated proton channel Hv1 is a newly discovered ion channel that is highly conserved among species. It is known that Hv1 is not only expressed in peripheral immune cells but also one of the major ion channels expressed in tissue-resident microglia of the central nervous systems (CNS). One key role for Hv1 is its interaction with NADPH oxidase 2 (NOX2) to regulate reactive oxygen species (ROS) and cytosolic pH. Emerging data suggest that excessive ROS production increases and requires proton currents through Hv1 in the injured CNS, and manipulations that ablate Hv1 expression or induce loss of function may provide neuroprotection in CNS injury models including stroke, traumatic brain injury, and spinal cord injury. Recent data demonstrating microglial Hv1-mediated signaling in the pathophysiology of the CNS injury further supports the idea that Hv1 channel may function as a key mechanism in posttraumatic neuroinflammation and neurodegeneration. In this review, we summarize the main findings of Hv1, including its expression pattern, cellular mechanism, role in aging, and animal models of CNS injury and disease pathology. We also discuss the potential of Hv1 as a therapeutic target for CNS injury.en_US
dc.description.urihttps://doi.org/10.3389/fncel.2021.662971en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Cellular Neuroscienceen_US
dc.rightsCopyright © 2021 He, Ritzel and Wu.en_US
dc.subjectNOX2en_US
dc.subjectROSen_US
dc.subjectacidificationen_US
dc.subjectmicrogliaen_US
dc.subjectspinal cord injuryen_US
dc.subjectstrokeen_US
dc.subjecttraumatic brain injuryen_US
dc.subjectvoltage-gated proton channel Hv1en_US
dc.titleFunctions and Mechanisms of the Voltage-Gated Proton Channel Hv1 in Brain and Spinal Cord Injuryen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fncel.2021.662971
dc.identifier.pmid33897377
dc.source.volume15
dc.source.beginpage662971
dc.source.endpage
dc.source.countrySwitzerland


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