Show simple item record

dc.contributor.authorLitvan, Irene
dc.contributor.authorProudfoot, James A
dc.contributor.authorMartin, Eden R
dc.contributor.authorStandaert, David
dc.contributor.authorRiley, David
dc.contributor.authorHall, Deborah
dc.contributor.authorMarras, Connie
dc.contributor.authorBayram, Ece
dc.contributor.authorDubinsky, Richard M
dc.contributor.authorBordelon, Yvette
dc.contributor.authorReich, Stephen
dc.contributor.authorShprecher, David
dc.contributor.authorKluger, Benzi
dc.contributor.authorCunningham, Christopher
dc.contributor.authorSchellenberg, Gerard D
dc.contributor.authorJankovic, Joseph
dc.date.accessioned2021-04-28T15:02:11Z
dc.date.available2021-04-28T15:02:11Z
dc.date.issued2021-04-09
dc.identifier.urihttp://hdl.handle.net/10713/15531
dc.description.abstractSeveral genetic and environmental factors have been reported in progressive supranuclear palsy (PSP), although none were identified as a definitive cause. We aimed to explore potential gene-environment interactions in PSP. Two hundred and ninety two PSP cases and 292 controls matched for age, sex, and race from the ENGENE-PSP were analyzed to determine the association between PSP and minor alleles of 5 single nucleotide polymorphisms (SNPs) in 4 genes (MAPT, MOBP, EIF2AK3, and STX6), which were previously associated with PSP risk. Interactions between these SNPs and environmental factors, including previously reported occupational and agricultural risk factors for PSP, were assessed for PSP odds and age of symptom onset. Minor alleles of MAPTrs242557 and EIF2AK3rs7571971 were individually associated with increased odds; MAPTrs8070723 minor alleles were associated with lower PSP odds. There were several gene-environment interactions for PSP odds and age of symptom onset, however, they did not remain significant after FDR-correction. Larger scale studies are required to determine potential interactions.en_US
dc.description.urihttps://doi.org/10.3389/fneur.2021.664796en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Neurologyen_US
dc.rightsCopyright © 2021 Litvan, Proudfoot, Martin, Standaert, Riley, Hall, Marras, Bayram, Dubinsky, Bordelon, Reich, Shprecher, Kluger, Cunningham, Schellenberg and Jankovic.en_US
dc.subjectenvironmenten_US
dc.subjectepidemiologyen_US
dc.subjectgeneen_US
dc.subjectprogressive supranuclear palsyen_US
dc.subjectrisk factorsen_US
dc.titleGene-Environment Interactions in Progressive Supranuclear Palsyen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fneur.2021.664796
dc.identifier.pmid33897612
dc.source.volume12
dc.source.beginpage664796
dc.source.endpage
dc.source.countrySwitzerland


This item appears in the following Collection(s)

Show simple item record