Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review
Author
Talaie, TaraDiChiacchio, Laura
Prasad, Nikhil K
Pasrija, Chetan
Julliard, Walker
Kaczorowski, David J
Zhao, Yunge
Lau, Christine L
Date
2021-01-07Journal
Transplantation DirectPublisher
Wolters Kluwer HealthType
Article
Metadata
Show full item recordAbstract
Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments have emerged for clinical use. Novel strategies are still needed to improve outcomes after lung transplantation. In this review, we discuss the underlying mechanisms of transplanted LIRI, potential modifiable targets, current practices, and areas of ongoing investigation to reduce LIRI and primary graft dysfunction in lung transplant recipients. © 2021 Lippincott Williams and Wilkins. All rights reserved.Rights/Terms
Copyright © 2020 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.Identifier to cite or link to this item
http://hdl.handle.net/10713/15518ae974a485f413a2113503eed53cd6c53
10.1097/TXD.0000000000001104
Scopus Count
Collections
Related articles
- Budesonide instillation immediately after reperfusion ameliorates ischemia/reperfusion-induced injury in the transplanted lung of rat.
- Authors: Gao W, Meng QM, Cui XG
- Issue date: 2017 Nov - Dec
- Surfactant pretreatment decreases long-term damage after ischemia-reperfusion injury of the lung.
- Authors: van der Kaaij NP, Kluin J, Haitsma JJ, den Bakker MA, Lambrecht BN, Lachmann B, de Bruin RW, Bogers AJ
- Issue date: 2009 Feb
- Ischemia of the lung causes extensive long-term pulmonary injury: an experimental study.
- Authors: van der Kaaij NP, Kluin J, Haitsma JJ, den Bakker MA, Lambrecht BN, Lachmann B, de Bruin RW, Bogers AJ
- Issue date: 2008 Mar 26
- The interaction between Toll-like receptor 4 signaling pathway and hypoxia-inducible factor 1α in lung ischemia-reperfusion injury.
- Authors: Zhou Z, Zhu X, Chen J, Yang S, Sun R, Yang G
- Issue date: 2014 May 1
- Mechanisms of lung ischemia-reperfusion injury.
- Authors: Laubach VE, Sharma AK
- Issue date: 2016 Jun