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    Multimodal Neuroimaging Study of Visual Plasticity in Schizophrenia

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    Author
    Wijtenburg, S Andrea
    West, Jeffrey
    Korenic, Stephanie A
    Kuhney, Franchesca
    Gaston, Frank E
    Chen, Hongji
    Rowland, Laura M
    Date
    2021-04-01
    Journal
    Frontiers in Psychiatry
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fpsyt.2021.644271
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046908/
    Abstract
    Schizophrenia is a severe mental illness with visual learning and memory deficits, and reduced long term potentiation (LTP) may underlie these impairments. Recent human fMRI and EEG studies have assessed visual plasticity that was induced with high frequency visual stimulation, which is thought to mimic an LTP-like phenomenon. This study investigated the differences in visual plasticity in participants with schizophrenia and healthy controls. An fMRI visual plasticity paradigm was implemented, and proton magnetic resonance spectroscopy data were acquired to determine whether baseline resting levels of glutamatergic and GABA metabolites were related to visual plasticity response. Adults with schizophrenia did not demonstrate visual plasticity after family-wise error correction; whereas, the healthy control group did. There was a significant regional difference in visual plasticity in the left visual cortical area V2 when assessing group differences, and baseline GABA levels were associated with this specific ROI in the SZ group only. Overall, this study suggests that visual plasticity is altered in schizophrenia and related to basal GABA levels.
    Rights/Terms
    Copyright © 2021 Wijtenburg, West, Korenic, Kuhney, Gaston, Chen and Rowland.
    Keyword
    GABA
    fMRI
    glutamate
    healthy adults
    magnetic resonance spectroscopy
    schizophrenia
    visual plasticity
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/15483
    ae974a485f413a2113503eed53cd6c53
    10.3389/fpsyt.2021.644271
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