Multimodal Neuroimaging Study of Visual Plasticity in Schizophrenia
Author
Wijtenburg, S AndreaWest, Jeffrey
Korenic, Stephanie A
Kuhney, Franchesca
Gaston, Frank E
Chen, Hongji
Rowland, Laura M
Date
2021-04-01Journal
Frontiers in PsychiatryPublisher
Frontiers Media S.A.Type
Article
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https://doi.org/10.3389/fpsyt.2021.644271https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046908/
Abstract
Schizophrenia is a severe mental illness with visual learning and memory deficits, and reduced long term potentiation (LTP) may underlie these impairments. Recent human fMRI and EEG studies have assessed visual plasticity that was induced with high frequency visual stimulation, which is thought to mimic an LTP-like phenomenon. This study investigated the differences in visual plasticity in participants with schizophrenia and healthy controls. An fMRI visual plasticity paradigm was implemented, and proton magnetic resonance spectroscopy data were acquired to determine whether baseline resting levels of glutamatergic and GABA metabolites were related to visual plasticity response. Adults with schizophrenia did not demonstrate visual plasticity after family-wise error correction; whereas, the healthy control group did. There was a significant regional difference in visual plasticity in the left visual cortical area V2 when assessing group differences, and baseline GABA levels were associated with this specific ROI in the SZ group only. Overall, this study suggests that visual plasticity is altered in schizophrenia and related to basal GABA levels.Rights/Terms
Copyright © 2021 Wijtenburg, West, Korenic, Kuhney, Gaston, Chen and Rowland.Keyword
GABAfMRI
glutamate
healthy adults
magnetic resonance spectroscopy
schizophrenia
visual plasticity
Identifier to cite or link to this item
http://hdl.handle.net/10713/15483ae974a485f413a2113503eed53cd6c53
10.3389/fpsyt.2021.644271
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