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dc.contributor.authorBooth, Jayaum S
dc.contributor.authorGoldberg, Eric
dc.contributor.authorPatil, Seema A
dc.contributor.authorBarnes, Robin S
dc.contributor.authorGreenwald, Bruce D
dc.contributor.authorSztein, Marcelo B
dc.date.accessioned2021-04-23T17:36:08Z
dc.date.available2021-04-23T17:36:08Z
dc.date.issued2021-04-19
dc.identifier.urihttp://hdl.handle.net/10713/15478
dc.description.abstractThe impact of aging on the immune system is unequivocal and results in an altered immune status termed immunosenescence. In humans, the mechanisms of immunosenescence have been examined almost exclusively in blood. However, most immune cells are present in tissue compartments and exhibit differential cell (e.g., memory T cells -TM) subset distributions. Thus, it is crucial to understand immunosenescence in tissues, especially those that are exposed to pathogens (e.g., intestine). Using a human model of oral live attenuated typhoid vaccine, Ty21a, we investigated the effect of aging on terminal ileum (TI) tissue resident memory T (TRM) cells. TRM provide immediate adaptive effector immune responsiveness at the infection site. However, it is unknown whether aging impacts TRM S. Typhi-responsive cells at the site of infection (e.g., TI). Here, we determined the effect of aging on the induction of TI S. Typhi-responsive TRM subsets elicited by Ty21a immunization.en_US
dc.description.urihttps://doi.org/10.1186/s12979-021-00227-yen_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofImmunity & Ageing : I & Aen_US
dc.subjectAgingen_US
dc.subjectOral vaccineen_US
dc.subjectTerminal ileum LPMCen_US
dc.subjectTissue resident memory T cellsen_US
dc.subjectTy21aen_US
dc.subjectVaccine-induced responsesen_US
dc.titleAge-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humansen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12979-021-00227-y
dc.identifier.pmid33874975
dc.source.volume18
dc.source.issue1
dc.source.beginpage19
dc.source.endpage
dc.source.countryUnited States
dc.source.countryEngland


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