Risks and benefits of antioxidant dietary supplement use during cancer treatment: protocol for a scoping review
Author
Wieland, L. SusanMoffet, Ilana
Shade, Sydney
Emadi, Ashkan
Knott, Cheryl
Gorman, Emily F.
D'Adamo, Christopher
Date
2021-04-13Journal
BMJ OpenPublisher
BMJ Publishing GroupType
Article
Metadata
Show full item recordAbstract
Introduction: Antioxidant dietary supplements are used by many patients with cancer to reduce the side effects of chemotherapy and improve prognosis. While some research indicates oral antioxidant supplementation reduces side effects and improves patient survival, other studies suggest the use of antioxidant dietary supplements may interfere with chemotherapy and reduce its curative effects. There is a need to clarify the evidence base on the impact of dietary antioxidant supplementation during chemotherapy on both side effect and treatment efficacy outcomes. We will use a scoping review approach to identify what systematic review evidence exists regarding beneficial and harmful effects of dietary antioxidant supplements when used during cancer treatment. Methods and analysis: We will use Arksey & O'Malley and Joanna Briggs Institute methods for scoping reviews. We will systematically search PubMed, Embase, CINAHL, Scopus, Dissertations & Theses Global and the Cochrane Library from inception to October 2020. Systematic reviews of randomised controlled trials of oral dietary antioxidant supplements used by participants receiving curative chemotherapy, radiotherapy or other biological therapy for cancer will be eligible. Two reviewers will screen citations and full texts for inclusion and chart data on research questions from included reviews. Two reviewers will assess the overall confidence in systematic review results using A Measurement Tool to Assess Systematic Reviews-2 (AMSTAR-2), and summarised evidence will focus on reviews rated at high or moderate overall confidence. Tables will be used to map existing evidence and identify evidence gaps for safety and effectiveness outcomes.Sponsors
National Center for Complementary and Integrative HealthIdentifier to cite or link to this item
http://hdl.handle.net/10713/15456ae974a485f413a2113503eed53cd6c53
10.1136/bmjopen-2020-047200
Scopus Count
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc/4.0/
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