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dc.contributor.authorGillespie, Andrea H.
dc.contributor.authorDoctor, Allan
dc.date.accessioned2021-04-21T15:26:16Z
dc.date.available2021-04-21T15:26:16Z
dc.date.issued2021-04-01
dc.identifier.urihttp://hdl.handle.net/10713/15454
dc.description.abstractRed Blood Cells (RBCs) have been increasingly recognized to play important roles in hemostasis and the mechanisms by which they do so continue to be elucidated. First and foremost, RBC biomechanics are the principal determinant of viscosity and flow dynamics of blood, which strongly influence all features of hemostasis. Of note, morphologic pathology, such as that found in sickle cell disease, leads to increased risk of thrombotic disease. RBC surface interactions govern signaling between platelets and RBCs and also aid in the conversion of prothrombin to thrombin. Additionally, RBCs generate microparticles which have been shown to reduce clotting time. Finally, blood clot structure and maturation are dependent on the inclusion of RBCs in forming thrombi. Here, we review the above mechanisms of RBC contribution to hemostasis.en_US
dc.description.urihttps://doi.org/10.3389/fped.2021.629824en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Pediatricsen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectaggregationen_US
dc.subjecthemostasisen_US
dc.subjectmicroparticlesen_US
dc.subjectphosphatidylserineen_US
dc.subjectred blood cell(s)en_US
dc.subjectshear rateen_US
dc.titleRed Blood Cell Contribution to Hemostasisen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fped.2021.629824
dc.identifier.pmid33869111
dc.source.volume9


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